DR.Bentzen: Function that calculates TCP according Bentzen (log Poisson)...
In kbolab/moddicom: Package for handling DICOM RT files

Description Usage Arguments Details References

This function calculates the Tumor Control Probability according the Bentzen (log Poisson) model.

1	DR.Bentzen(doses, TD50 = 45, gamma50 = 1.5, a = 1)

`doses`	Either a `dvhmatrix` class object or a vector with nominal doses
`TD50`	The value of dose that gives the 50% of probability of outcome
`gamma50`	The slope of dose/response curve at 50% of probability
`a`	Value for parallel-serial correlation in radiobiological response

In Bentzen paper dose/response curves were described both for tumor and normal tissue response. In moddicom implementation log Poisson model starts from the DR.Warkentin equation but calculating the relationship of response with the log Dose as follows:

TCP=≤ft (\frac{1}{2} \right )^{≤ft (\frac{TD_{50}}{D} \right )^{\frac{2γ_{50}}{log2}}}

In the model equation D can be either the nominal dose or the EUD as calculated by DVH.eud function.

Bentzen SM, Tucker SL. Quantifying the position and steepness of radiation dose-response curves. Int J Radiat Biol. 1997 May;71(5):531-42. Review. PubMed PMID: 9191898.

kbolab/moddicom documentation built on Nov. 29, 2020, 9:11 p.m.