Description Usage Arguments Details Value References
This function calculates the Normal Tissue Complication Probability according the Niemierko model.
1 | DR.Niemierko(doses, TD50 = 45, gamma50 = 1.5, a = 1)
|
doses |
Either a |
TD50 |
The value of dose that gives the 50% of probability of outcome |
gamma50 |
The slope of dose/response curve at 50% of probability |
a |
Value for parallel-serial correlation in radiobiological response |
This model can be used to compute Tumor Control Probability (TCP) too. It is the translation of a loglogit generalized linear model as function of TD_{50} and γ_{50}. The model equation is:
(N)TCP=\frac{1}{1+ ({\frac{TD_{50}}{D}})^{4γ_{50}}}
D can be either the nominal dose or the EUD as calculated by DVH.eud
function.
A vector with NTCP(s) calculated according Niemierko model.
Gay HA, Niemierko A. A free program for calculating EUD-based NTCP and TCP in external beam radiotherapy. Phys Med. 2007 Dec;23(3-4):115-25. Epub 2007 Sep 7. PubMed PMID: 17825595.
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