Compute differential causal effects (dce) on (biological) networks. Given observational samples from a control experiment and non-control (e.g., cancer) for two genes A and B, we can compute differential causal effects with a (generalized) linear regression. If the causal effect of gene A on gene B in the control samples is different from the causal effect in the non-control samples the dce will differ from zero. We regularize the dce computation by the inclusion of prior network information from pathway databases such as KEGG.
Package details |
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Bioconductor views | DifferentialExpression GeneExpression GraphAndNetwork KEGG Network NetworkEnrichment Regression Software StatisticalMethod |
Maintainer | |
License | GPL-3 |
Version | 1.3.5 |
URL | https://github.com/cbg-ethz/dce |
Package repository | View on GitHub |
Installation |
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