ToxoLopit: Whole-cell spatial proteome of Toxoplasma: molecular anatomy...

In lgatto/pRolocdata: Data accompanying the pRoloc package

Whole-cell spatial proteome of Toxoplasma: molecular anatomy of an apicomplexan cell

Description

Data from 'Whole-cell spatial proteome of Toxoplasma: molecular anatomy of an apicomplexan cell'

Apicomplexan parasites are the causative agents of major human diseases and food insecurity and owe their considerable success to novel, highly specialized cell compartments and structures. These adaptations facilitate the recognition and non-destructive penetration of their host cells, and elaborate reengineering of these cells to promote growth, dissemination and active countering of host defense responses. The evolution of apicomplexan compartments is concomitant with great proteomic novelty that defines these new cell organizations and functions and, hence, approximately half of their proteins are unique and uncharacterized. Consequently, apicomplexan cells are relatively poorly understood. Here we employ the hyperLOPIT cell spatial proteomic method to the apicomplexan Toxoplasma gondii and define the steady-state subcellular location of thousands of proteins simultaneously giving comprehensive definition to these cells and their compartments. These data, moreover, provide new insight into the spatial organizations of protein expression, adaptation to hosts, and the underlying evolutionary trajectories of these parasites.

Usage

  data("Barylyuk2020ToxoLopit")

Format

The data is an instance of class MSnSet from package MSnbase.

Examples

  data(Barylyuk2020ToxoLopit)
  Barylyuk2020ToxoLopit
  pData(Barylyuk2020ToxoLopit)
  exprs(Barylyuk2020ToxoLopit)[1:3,1:3]
  
  library("pRoloc")
  plot2D(Barylyuk2020ToxoLopit, main = "Davies 2018 HeLa - wt")

lgatto/pRolocdata documentation built on Oct. 17, 2024, 10:16 p.m.