Description Usage Arguments Value
View source: R/SyntheticDoublets.R
This function creates synthetic doublets by averaging gene expression profiles from each combination of clusters to generate deconvolution profiles for each type of doublet.
1 2 3 4 5 6 7 8 9 10 | SyntheticDoublets(
data,
groups,
groupsMedoids,
newMedoids,
num_doubs,
only50,
location,
seed
)
|
data |
Processed data from Clean_Up_Input (or Remove_Cell_Cycle). |
groups |
Processed groups file from Clean_Up_Input. |
groupsMedoids |
New groups file based on blacklisted clusters from Blacklist_Groups |
newMedoids |
New combined medoids from Blacklist_groups. |
num_doubs |
The user defined number of doublets to make for each pair of clusters |
only50 |
Use only synthetic doublets created with 50%/50% mix of parent cells, as opposed to the extended option of 30%/70% and 70%/30%, default is TRUE. |
location |
Directory where output should be stored |
seed |
Set a random seed. |
averagesAverages = average deconvolution profiles for each combination of cell types.
doubletCellsInput2 = deconvolution profiles for synthetic doublet cells (for quality control).
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