twotcm1k_model: Model: Two Tissue Compartment Model with Irreversible...

In mathesong/kinfitr: Kinetic Modelling of PET Time Activity Curves

Model: Two Tissue Compartment Model with Irreversible Trapping

Description

This is the Two Tissue Compartment Model with Irreversible Trapping model itself by which predicted values are generated.

Usage

twotcm1k_model(t_tac, input, K1, k2, k3, k4, Kb, vB)

Arguments

t_tac	Numeric vector of times for each frame in minutes. We use the time halfway through the frame as well as a zero.
input	Data frame containing the blood, plasma, and parent fraction concentrations over time. This can be generated using the blood_interp function.
K1	Parameter value for K1
k2	Parameter value for k2
k3	Parameter value for k3
k4	Parameter value for k4
Kb	Parameter value for Kb
vB	Parameter value for vB

Value

A numeric vector of the predicted values of the TAC in the target region.

Author(s)

Granville J Matheson, [e-mail]

References

Rizzo, G., Veronese, M., Tonietto, M., Zanotti-Fregonara, P., Turkheimer, F. E., & Bertoldo, A. (2014). Kinetic modeling without accounting for the vascular component impairs the quantification of [11C] PBR28 brain PET data. Journal of Cerebral Blood Flow & Metabolism, 34(6), 1060-1069.

Examples

## Not run: 
twotcm1k_model(t_tac, input, K1 = 0.1, k2 = 0.08, k3 = 0.05, k4 = 0.02, Kb = 0.25, vB = 0.05)

## End(Not run)

mathesong/kinfitr documentation built on Sept. 17, 2024, 4:45 a.m.