mervesa/HiCDCPlus: Hi-C Direct Caller Plus

Systematic 3D interaction calls and differential analysis for Hi-C and HiChIP. The HiC-DC+ (Hi-C/HiChIP direct caller plus) package enables principled statistical analysis of Hi-C and HiChIP data sets – including calling significant interactions within a single experiment and performing differential analysis between conditions given replicate experiments – to facilitate global integrative studies. HiC-DC+ estimates significant interactions in a Hi-C or HiChIP experiment directly from the raw contact matrix for each chromosome up to a specified genomic distance, binned by uniform genomic intervals or restriction enzyme fragments, by training a background model to account for random polymer ligation and systematic sources of read count variation.

Getting started

Package details

Bioconductor views DNA3DStructure HiC Normalization Software
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
mervesa/HiCDCPlus documentation built on April 14, 2021, 9:13 p.m.