Description Usage Arguments Details References
View source: R/Dose.Response.R View source: R/modeling.R
This function calculates the Tumor Control Probability according the Bentzen (log Poisson) model.
1 | DR.Bentzen(doses, TD50 = 45, gamma50 = 1.5, a = 1)
|
doses |
Either a |
TD50 |
The value of dose that gives the 50% of probability of outcome |
gamma50 |
The slope of dose/response curve at 50% of probability |
a |
Value for parallel-serial correlation in radiobiological response |
In Bentzen paper dose/response curves were described both for tumor and normal tissue response.
In moddicom implementation log Poisson model starts from the DR.Warkentin
equation but
calculating the relationship of response with the log Dose as follows:
TCP=≤ft (\frac{1}{2} \right )^{≤ft (\frac{TD_{50}}{D} \right )^{\frac{2γ_{50}}{log2}}}
In the model equation D can be either the nominal dose or the EUD as calculated by DVH.eud
function.
Bentzen SM, Tucker SL. Quantifying the position and steepness of radiation dose-response curves. Int J Radiat Biol. 1997 May;71(5):531-42. Review. PubMed PMID: 9191898.
Add the following code to your website.
For more information on customizing the embed code, read Embedding Snippets.