RadAgent: Package for handling DICOM RT files

Description Usage Arguments Details Value References

View source: R/Dose.Response.R View source: R/modeling.R

This function calculates the Tumor Control Probability according the Munro/Gilbert/Kallman model.

1	DR.Munro(doses, TD50 = 45, gamma50 = 1.5, a = 1)

`doses`	Either a `dvhmatrix` class object or a vector with nominal doses
`TD50`	The value of dose that gives the 50% of probability of outcome
`gamma50`	The slope of dose/response curve at 50% of probability
`a`	Value for parallel-serial correlation in radiobiological response

This model is an empyrical dose/response curve that fits experimental data. In their paper authors assume this curve to be equivalent to a Poisson model. The original model equation is:

TCP=e^{-EN_{0}e^{\frac{-D}{D_{0}}}}

E is a numerical parameter that is related to tumor radiosensitivity, N_{0} is the total initial number of tumor clonogenic cells, D is the delivered dose and D_{0} is the increment of dose that lowers survival to 37 per cent. In our implementation Munro/Gilbert/Kallman model has been referenced to TD_{50} and γ_{50} as follows:

TCP=2^{e^{eγ_{50}(1-\frac{D}{TD_{50}})}}

In the model equation D can be either the nominal dose or the EUD as calculated by DVH.eud function.

A vector with TCP calculated according Munro/Gilbert/Kallman model.

Munro TR, Gilbert CW. The relation between tumour lethal doses and the radiosensitivity of tumour cells. Br J Radiol. 1961 Apr;34:246-51. PubMed PMID: 13726846.

robertogattabs/RadAgent documentation built on June 30, 2018, 12:02 a.m.