DR.Niemierko: Function that calculates (N)TCP according Niemierko model

In robertogattabs/RadAgent: Package for handling DICOM RT files

Description

This function calculates the Normal Tissue Complication Probability according the Niemierko model.

Usage

DR.Niemierko(doses, TD50 = 45, gamma50 = 1.5, a = 1)

Arguments

doses	Either a dvhmatrix class object or a vector with nominal doses
TD50	The value of dose that gives the 50% of probability of outcome
gamma50	The slope of dose/response curve at 50% of probability
a	Value for parallel-serial correlation in radiobiological response

Details

This model can be used to compute Tumor Control Probability (TCP) too. It is the translation of a loglogit generalized linear model as function of TD_{50} and γ_{50}. The model equation is:

(N)TCP=\frac{1}{1+ ({\frac{TD_{50}}{D}})^{4γ_{50}}}

D can be either the nominal dose or the EUD as calculated by DVH.eud function.

Value

A vector with NTCP(s) calculated according Niemierko model.

References

Gay HA, Niemierko A. A free program for calculating EUD-based NTCP and TCP in external beam radiotherapy. Phys Med. 2007 Dec;23(3-4):115-25. Epub 2007 Sep 7. PubMed PMID: 17825595.

robertogattabs/RadAgent documentation built on June 30, 2018, 12:02 a.m.