estimateRedundancy: Estimates the redundancy of enriched gene sets

Description Usage Arguments Value Examples

Description

Wrapper around the 'mgsa' method

Usage

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estimateRedundancy(scores, gsets, Gdiffexp)

Arguments

scores

Dataframe from 'r packagedocs::rd_link(testUnidirectionality())' containing the filtered enrichment scores for every gene set

gsets

Named list containing character vectors for each gene set

Gdiffexp

Character vector of differentially expressed genes

Value

Numeric vector containing for every gene set (in the same order the scores dataframe) its relevance compared with other gene sets, higher is better

Examples

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Eoi = matrix(rnorm(1000*3, sd=0.5), 1000, 3, dimnames=list(1:1000, c(1,2,3)))
Eoi[1:100,1] = Eoi[1:100,1] + 4 # the first 100 genes are more upregulated in the first condition
barycoords = transformBarycentric(Eoi)
Gdiffexp = (1:1000)[barycoords$r > 1]

# a and b are redundant, but a is stronger enriched
gsets = list(a=1:50, b=c(1:50, 100:110), c=200:500)
scores = testUnidirectionality(barycoords, gsets, Gdiffexp=(1:1000)[barycoords$r > 1])
scores$redundancy = estimateRedundancy(scores, gsets, Gdiffexp)
scores[scores$gsetid == "a", "redundancy"] > scores[scores$gsetid == "b", "redundancy"]

saeyslab/triwise documentation built on May 29, 2019, 12:56 p.m.