inf_hist_prop_prior_v2_and_v4: Infection history gibbs proposal

In seroanalytics/serosolver: Inference Framework for Serological Data

Infection history gibbs proposal

Description

Generates a new infection history matrix and corresponding individual likelihoods, using a gibbs sampler from the infection history prior. See inf_hist_prop_prior_v3, as inputs are very similar.

Usage

inf_hist_prop_prior_v2_and_v4(
  theta,
  unique_theta_indices,
  unique_biomarker_groups,
  indiv_group_indices,
  infection_history_mat,
  infection_history_mat_indices,
  likelihoods_pre_proposal,
  sampled_indivs,
  n_times_samp_vec,
  age_mask,
  sample_mask,
  n_alive,
  n_infections,
  n_infected_group,
  prior_lookup,
  proposal_inf_hist_indiv_swap_ratio,
  swap_distance,
  propose_from_prior,
  shape1,
  shape2,
  possible_exposure_times,
  possible_exposure_times_indices,
  sample_times,
  type_data_start,
  biomarker_groups,
  sample_data_start,
  antibody_data_start,
  nrows_per_sample,
  cum_nrows_per_individual_in_data,
  cum_nrows_per_individual_in_repeat_data,
  popn_group_id_vec,
  biomarker_id_indices,
  start_level_indices,
  starting_antibody_levels,
  births,
  antigenic_map_long,
  antigenic_map_short,
  antigenic_distances,
  antibody_data,
  antibody_data_repeats,
  n_measurements_total,
  repeat_indices,
  repeat_data_exist,
  measurement_shifts,
  proposal_iter,
  accepted_iter,
  proposal_swap,
  accepted_swap,
  overall_swap_proposals,
  overall_add_proposals,
  time_sample_probs,
  total_alive,
  data_types,
  obs_weights,
  indiv_possible_exposure_times_indices,
  indiv_poss_exp_times_start,
  indiv_poss_exp_times_end,
  timevarying_groups = FALSE,
  temp = 1,
  solve_likelihood = TRUE
)

Arguments

theta	NumericMatrix, the named model parameters used to solve the model
indiv_group_indices	IntegerVector, for each individual, which unique group (for the kinetics parameters) do they belong to?
infection_history_mat	IntegerMatrix the matrix of 1s and 0s corresponding to individual infection histories
likelihoods_pre_proposal	NumericVector, the current likelihoods for each individual before proposing new infection histories
sampled_indivs	IntegerVector, indices of sampled individuals
age_mask	IntegerVector, length of the number of individuals, with indices specifying first time period that an individual can be infected (indexed from 1, such that a value of 1 allows an individual to be infected in any time period)
sample_mask	IntegerVector, length of the number of individuals, with indices specifying last time period that an individual can be infected (ie. last time a sample was taken)
n_alive	IntegerMatrix, number of columns is the number of time periods that an individual could be infected, giving the number of individual alive in each time period. Number of rows is the number of distinct groups.
n_infections	IntegerMatrix, the number of infections in each year (columns) for each group (rows)
n_infected_group	IntegerVector, the total number of infections across all times in each group
prior_lookup	arma::cube, the pre-computed lookup table for the beta prior on infection histories, dimensions are number of infections, time, and group
proposal_inf_hist_indiv_swap_ratio	double, gives the proportion of proposals that will be swap steps (ie. swap contents of two cells in infection_history rather than adding/removing infections)
swap_distance	int, in a swap step, how many time steps either side of the chosen time period to swap with
shape1	double, shape1 (alpha) parameter for beta prior on infection probability
shape2	double, shape2 (beta) parameter for beta prior on infection probability
possible_exposure_times	NumericVector, the times that individuals could be infected
possible_exposure_times_indices	IntegerVector, indexing vector from 0:(number of exposure times-1)
sample_times	NumericVector, the vector of real times that samples were taken
cum_nrows_per_individual_in_data	IntegerVector, How many rows in the antibody data correspond to each individual?
cum_nrows_per_individual_in_repeat_data	IntegerVector, For the repeat data (ie. already calculated these antibody levels), how many rows in the antibody data correspond to each individual?
popn_group_id_vec	IntegerVector, vector with 1 entry per individual, giving the group ID of that individual
biomarker_id_indices	IntegerVector, For each antibody measurement, corresponding entry in antigenic map
antigenic_map_long	arma::mat, the collapsed cross reactivity map for long term boosting, after multiplying by sigma1, see create_cross_reactivity_vector
antigenic_map_short	arma::mat, the collapsed cross reactivity map for short term boosting, after multiplying by sigma2, see create_cross_reactivity_vector
antigenic_distances	NumericVector matching the dimensions of antigenic_map_long and antigenic_map_short, but with the raw antigenic distances between strains
antibody_data	NumericVector, data for all individuals for the first instance of each calculated antibody level
antibody_data_repeats	NumericVector, the repeat antibody data for all individuals (ie. do not solve the same antibody level twice)
repeat_indices	IntegerVector, which index in the main data vector does each entry in repeat_data correspond to ie. which calculated antibody level in predicted_antibody_levels should be used for each observation?
measurement_shifts	NumericVector, if length matches the length of data, adds these as measurement shifts to the antibody levels. If lengths do not match, is not used.
proposal_iter	IntegerVector, vector with entry for each individual, storing the number of infection history add/remove proposals for each individual.
accepted_iter	IntegerVector, vector with entry for each individual, storing the number of accepted infection history add/remove proposals for each individual.
proposal_swap	IntegerVector, vector with entry for each individual, storing the number of proposed infection history swaps
accepted_swap	IntegerVector, vector with entry for each individual, storing the number of accepted infection history swaps
total_alive	IntegerVector, giving the total number of potential infection events for each group. This only applies to prior version 4. If set to a vector of values -1, then this is ignored.
temp	double, temperature for parallel tempering MCMC
solve_likelihood	bool, if FALSE does not solve likelihood when calculating acceptance probability
rows_per_indiv_in_samples	IntegerVector, How many rows in antibody data correspond to each individual, sample and repeat?
nrows_per_blood_sample	IntegerVector, Split the sample times and runs for each individual
data_type	int, defaults to 1 for discretized, bounded data. Set to 2 for continuous, bounded data

Value

an R list with 6 entries: 1) the vector replacing likelihoods_pre_proposal, corresponding to the new likelihoods per individual; 2) the matrix of 1s and 0s corresponding to the new infection histories for all individuals; 3-6) the updated entries for proposal_iter, accepted_iter, proposal_swap and accepted_swap.

See Also

Other infection_history_proposal: inf_hist_prop_prior_v3()

seroanalytics/serosolver documentation built on Aug. 18, 2024, 12:46 p.m.