R/mice_pot.R

In speegled/fosdata: Data for use with the book "Probability, Statistics, and Data: A Fresh Approach Using R", by Darrin Speegle and Bryan Clair

#' Mice on pot
#'
#' Wild type mice were injected with THC at various doses based on the weight of the mouse. The percent of baseline locomotion
#' was observed for each mouse.
#'
#' There is much more data of this type available in the paper. The authors tested the mice in numerous ways,
#' and they also compared wild type mice with serotonin 2A receptors knockout mice.
#'
#' From the authors: "Activation of cannabinoid CB1 receptors (CB1R) by delta9-tetrahydrocannabinol (THC) produces a variety of negative effects with major consequences in cannabis users that constitute important drawbacks for the use of cannabinoids as therapeutic agents. For this reason, there is a tremendous medical interest in harnessing the beneficial effects of THC. Behavioral studies carried out in mice lacking 5-HT2A receptors (5-HT2AR) revealed a remarkable 5-HT2AR-dependent dissociation in the beneficial antinociceptive effects of THC and its detrimental amnesic properties."
#'
#' @format A data frame with 46 observations of 2 variables
#' \describe{
#'   \item{group}{One of four levels, VEH (control) or the amount of THC in mg/kg the mouse was injected with.}
#'   \item{percent_of_act}{Percent of baseline locomotion activity}
#' }
#'
#' @source Viñals X, Moreno E, Lanfumey L, Cordomí A, Pastor A, de La Torre R, et al. (2015) Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors. PLoS Biol 13(7): e1002194. https://doi.org/10.1371/journal.pbio.1002194
"mice_pot"