FittingSingleDrug: Fitting single drug dose-response curve

In struckma/synergyfinder: Calculate and Visualize Synergy Scores for Drug Combinations

Description

A function to fit single drug dose-response curve with observed response data

Usage

FittingSingleDrug(response.mat, fixed = c(NA, NA, NA, NA),
  nan.handle = c("LL4", "L4"))

Arguments

response.mat	a matrix with first column as the drug concentrations and second column as the observed responses
fixed	a parameter to specify which parameters are fixed and at what value they are fixed. NAs for parameter that are not fixed.
nan.handle	a parameter to specify if L.4 function or LL.4 function is used when fitting with LL.4 produces NaNs.

Details

Single drug dose-response curve is fitted with a commonly used 4-paramter log-losistic (4PL) function.

Value

Fitted responses and fitted models are returned.

Author(s)

Liye He [e-mail]

References

Seber, G. A. F. and Wild, C. J (1989) Nonlinear Regression, New York: Wiley \& Sons (p. 330).

Examples

data("mathews_screening_data")
data <- ReshapeData(mathews_screening_data)
single.drug.fitted <- FittingSingleDrug(data$dose.response.mats[[1]])

struckma/synergyfinder documentation built on May 17, 2019, 11:18 p.m.