lipid.scores: Genetic risk scores for serum lipid levels
In tobyjohnson/gtx: Genetics ToolboX
Description
Usage
Format
Source
Description
Risk scores parameterised using GWAS meta-analysis results published
by the Global Lipid Genetics Consortium (Teslovich et al. Nature
2010). There are scores for four different lipid level phenotypes
(High Density Lipoprotein HDL; Low Density Lipoprotein LDL; Total
Cholesterol TC; Triglycerides TG), all parameterised using genome wide
significant SNPs reported in Supplementary Table 1 of Teslovich et
al. (2010).
Usage
1
Format
A data frame suitable for use with other functions in this package.
These scores are called HDL2010, LDL2010, TC2010 and TG2010, and have
coefficients in mg/dl per coded allele.
Additional scores based on larger numbers of SNPs are available separately...
LDL.prune.0.01 and there is an additional column in the data frame,
p-value, that should be used to threshold on. The coefficients are
back-calculates from Z scores and HapMap allele frequency data.
Source
For the publication by Teslovich et al. from which these
data were extracted see http://dx.doi.org/10.1038/nature09270.
tobyjohnson/gtx documentation built on Aug. 30, 2019, 8:07 p.m.
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Description Usage Format Source
Description
Risk scores parameterised using GWAS meta-analysis results published by the Global Lipid Genetics Consortium (Teslovich et al. Nature 2010). There are scores for four different lipid level phenotypes (High Density Lipoprotein HDL; Low Density Lipoprotein LDL; Total Cholesterol TC; Triglycerides TG), all parameterised using genome wide significant SNPs reported in Supplementary Table 1 of Teslovich et al. (2010).
Usage
1 |
Format
A data frame suitable for use with other functions in this package.
These scores are called HDL2010, LDL2010, TC2010 and TG2010, and have coefficients in mg/dl per coded allele.
Additional scores based on larger numbers of SNPs are available separately... LDL.prune.0.01 and there is an additional column in the data frame, p-value, that should be used to threshold on. The coefficients are back-calculates from Z scores and HapMap allele frequency data.
Source
For the publication by Teslovich et al. from which these data were extracted see http://dx.doi.org/10.1038/nature09270.
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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