pFstop: Operating characteristics of a single-arm trial with a binary...

In wiesenfa/BDP2: Bayesian Adaptive Designs for Phase II Trials with Binary Endpoint

Description

Determines the operating characteristics of a single-arm trial with a binary endpoint (success - failure) on the basis of analytical derivations. The design allows for futility stopping. Outputs are

• probability of futility stopping (P.futil) at each interim analysis

• cumulative stopping probability up to the interim (P.futil.cum).

Usage

pFstop(p, vn.int, v.crit)

Arguments

p	true response rate
vn.int	vector of sample sizes at the interim analyses
v.crit	vector of critical boundaries for futility stopping at the interim analyses (stop for futility if number of successes <= boundary). Choose boundary=-1 if no stopping is allowed.

Examples

pFstop(p=0.3,vn.int=c(3,9,13,18,20),v.crit=c(0,1,2,3,3))

wiesenfa/BDP2 documentation built on April 11, 2021, 8:06 p.m.