pFstopEcall: operating characteristics of a single-arm trial with a binary...

In wiesenfa/BDP2: Bayesian Adaptive Designs for Phase II Trials with Binary Endpoint

Description

Determines the operating characteristics of a single-arm trial with a binary endpoint (success - failure) on the basis of analytical derivations. The design allows for futility stopping and evaluates efficacy at interim. Outputs are

• probability of calling efficacy (P.effic) at each interim analysis

• cumulative probability of calling efficacy up to the interim (P.effic.cum).

• probability of futility stopping (P.futil) at each interim analysis

• cumulative stopping probability up to the interim (P.futil.cum).

Usage

pFstopEcall(p, vn.int, v.critE, v.critF)

Arguments

p	true response rate
vn.int	vector of sample sizes at the interim analyses
v.critE	vector of critical boundaries for calling efficacy at the interim analyses (call efficacy if number of successes >= boundary)
v.critF	vector of critical boundaries for futility stopping at the interim analyses (stop for futility if number of successes <= boundary). Choose boundary=-1 if no stopping for futility is allowed.

Examples

pFstopEcall(p=0.3,vn.int=c(3,9,13,18,20),v.critE=4:8, v.critF=c(0,1,2,3,3))

wiesenfa/BDP2 documentation built on April 11, 2021, 8:06 p.m.