pRRopheticLogisticPredict: Predict from the CGP data using a logistic model

Description Usage Arguments Value Author(s)

View source: R/pRRophetic.R

Description

Predict from the CGP data using a logistic model.

Usage

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pRRopheticLogisticPredict(
  testMatrix,
  drug,
  tissueType = "all",
  batchCorrect = "eb",
  minNumSamples = 10,
  selection = -1,
  printOutput = TRUE,
  numGenesSelected = 1000,
  numSens = 15,
  numRes = 55
)

Arguments

testMatrix

a gene expression matrix with gene names as row ids and sample names as column ids.

drug

the name of the drug for which you would like to predict sensitivity, one of A.443654, A.770041, ABT.263, ABT.888, AG.014699, AICAR, AKT.inhibitor.VIII, AMG.706, AP.24534, AS601245, ATRA, AUY922, Axitinib, AZ628, AZD.0530, AZD.2281, AZD6244, AZD6482, AZD7762, AZD8055, BAY.61.3606, Bexarotene, BI.2536, BIBW2992, Bicalutamide, BI.D1870, BIRB.0796, Bleomycin, BMS.509744, BMS.536924, BMS.708163, BMS.754807, Bortezomib, Bosutinib, Bryostatin.1, BX.795, Camptothecin, CCT007093, CCT018159, CEP.701, CGP.082996, CGP.60474, CHIR.99021, CI.1040, Cisplatin, CMK, Cyclopamine, Cytarabine, Dasatinib, DMOG, Docetaxel, Doxorubicin, EHT.1864, Elesclomol, Embelin, Epothilone.B, Erlotinib, Etoposide, FH535, FTI.277, GDC.0449, GDC0941, Gefitinib, Gemcitabine, GNF.2, GSK269962A, GSK.650394, GW.441756, GW843682X, Imatinib, IPA.3, JNJ.26854165, JNK.9L, JNK.Inhibitor.VIII, JW.7.52.1, KIN001.135, KU.55933, Lapatinib, Lenalidomide, LFM.A13, Metformin, Methotrexate, MG.132, Midostaurin, Mitomycin.C, MK.2206, MS.275, Nilotinib, NSC.87877, NU.7441, Nutlin.3a, NVP.BEZ235, NVP.TAE684, Obatoclax.Mesylate, OSI.906, PAC.1, Paclitaxel, Parthenolide, Pazopanib, PD.0325901, PD.0332991, PD.173074, PF.02341066, PF.4708671, PF.562271, PHA.665752, PLX4720, Pyrimethamine, QS11, Rapamycin, RDEA119, RO.3306, Roscovitine, Salubrinal, SB.216763, SB590885, Shikonin, SL.0101.1, Sorafenib, S.Trityl.L.cysteine, Sunitinib, Temsirolimus, Thapsigargin, Tipifarnib, TW.37, Vinblastine, Vinorelbine, Vorinostat, VX.680, VX.702, WH.4.023, WO2009093972, WZ.1.84, X17.AAG, X681640, XMD8.85, Z.LLNle.CHO, ZM.447439.

tissueType

specify if you would like to traing the models on only a subset of the CGP cell lines (based on the tissue type from which the cell lines originated). This be one any of "all" (for everything, default option), "allSolidTumors" (everything except for blood), "blood", "breast", "CNS", "GI tract" ,"lung", "skin", "upper aerodigestive"

batchCorrect

The type of batch correction to be used. Options are "eb", "none", .....

minNumSamples

The minimum number of test samples, print an error if the number of columns of "testExprData" is below this threshold. A large number of test samples may be necessary to correct for batch effects.

selection

How should duplicate gene ids be handled. Default is -1 which asks the user. 1 to summarize by their or 2 to disguard all duplicates.

printOutput

Set to FALSE to supress output

numGenesSelected

Specifies how genes are selected for "variableSelectionMethod". Options are "tTests", "pearson" and "spearman".

numSens

The number of sensitive cell lines to be fit in the logistic regression model.

numRes

The number of resistant cell lines fit in the logistic regression model.

Value

A predicted probability of sensitive or resistant from the logistic regression model.

Author(s)

Paul Geeleher, Nancy Cox, R. Stephanie Huang


xlucpu/MOVICS documentation built on July 24, 2021, 9:23 p.m.