iDEA.louis: Correct the p-values using Louis method
In xzhoulab/iDEA: Integrative Differential Expression and Gene Set Enrichment Analysis
iDEA.louis R Documentation
Correct the p-values using Louis method
Description
A part of variance is missed when we use EM algorithm, since we should use the complete-data gradient vector or second derivative matrix rather than the incomplete data likelihood.
See details: "Thomas A. Louis. Finding the Observed Information Matrix when Using the EM Algorithm, Journal of the Royal Statistical Society.
Series B (Methodological) Vol. 44, No. 2 (1982), pp. 226-233".
Usage
iDEA.louis(object)
Arguments
object
iDEA object
...
Ignored
Value
Returns a iDEA object with corrected p-values stored in object@gsea.
xzhoulab/iDEA documentation built on Oct. 8, 2022, 8:54 a.m.
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| iDEA.louis | R Documentation |
Correct the p-values using Louis method
Description
A part of variance is missed when we use EM algorithm, since we should use the complete-data gradient vector or second derivative matrix rather than the incomplete data likelihood. See details: "Thomas A. Louis. Finding the Observed Information Matrix when Using the EM Algorithm, Journal of the Royal Statistical Society. Series B (Methodological) Vol. 44, No. 2 (1982), pp. 226-233".
Usage
iDEA.louis(object)
Arguments
object |
iDEA object |
... |
Ignored |
Value
Returns a iDEA object with corrected p-values stored in object@gsea.
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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