Indometh data frame has 66 rows and 3 columns of data on
the pharmacokinetics of indometacin (or, older spelling,
An object of class
c("nfnGroupedData", "nfGroupedData", "groupedData", "data.frame")
containing the following columns:
an ordered factor with containing the subject codes. The ordering is according to increasing maximum response.
a numeric vector of times at which blood samples were drawn (hr).
a numeric vector of plasma concentrations of indometacin (mcg/ml).
Each of the six subjects were given an intravenous injection of indometacin.
This dataset was originally part of package
nlme, and that has
methods (including for
Kwan, Breault, Umbenhauer, McMahon and Duggan (1976) Kinetics of Indomethacin absorption, elimination, and enterohepatic circulation in man. Journal of Pharmacokinetics and Biopharmaceutics 4, 255–280.
Davidian, M. and Giltinan, D. M. (1995) Nonlinear Models for Repeated Measurement Data, Chapman & Hall (section 5.2.4, p. 129)
Pinheiro, J. C. and Bates, D. M. (2000) Mixed-effects Models in S and S-PLUS, Springer.
SSbiexp for models fitted to this dataset.