Description Usage Format Details Note Source References Examples
The data are from a placebo-controlled clinical trial of 59 epileptics. Patients with partial seizures were enrolled in a randomized clinical trial of the anti-epileptic drug, progabide.
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A data frame with 295 observations on the following 5 variables.
id
a factor with 59 levels
treatment
a factor with levels placebo
and
progabide
age
a numeric vector
week
a numeric vector; 0 represents the baseline over the preceeding 8 weeks
nSeizures
a numeric vector; number of seizures
Participants in the study were randomized to either progabide or a placebo, as an adjuvant to the standard anti-epileptic chemotherapy. Progabide is an anti-epileptic drug whose primary mechanism of action is to enhance gamma-aminobutyric acid (GABA) content; GABA is the primary inhibitory neurotransmitter in the brain. Prior to receiving treatment, baseline data on the number of epileptic seizures during the preceding 8-week interval were recorded. Counts of epileptic seizures during 2-week intervals before each of four successive post-randomization clinic visits were recorded.
Original variable names have been adapted to R conventions. Data were
reshaped from wide to long format and the response named
nSeizures
.
http://biosun1.harvard.edu/~fitzmaur/ala
Thall PF, Vail SC (1990) Some covariance models for longitudinal count data with overdispersion. Biometrics 46:657-671
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