ntp: Developmental toxicity study of ethylene glycol (EG)

In ALA: Data sets and examples for the book "Applied Longitudinal Analysis"

Description

The data are from a development toxicity study of ethylene glycol (EG). Ethylene glycol is a high-volume industrial chemical used in many applications.

Usage

data(ntp)

Format

A data frame with 1028 observations on the following 4 variables.

id

a factor 94 with levels

dose

a numeric vector

weight

a numeric vector

malformed

a factor with levels no and yes (evidence of malformations)

Details

In a study of laboratory mice conducted through the National Toxicology Program (NTP), EG was administered at doses of 0, 750, 1500, or 3000 mg/kg/day to 94 pregnant mice (dams) over the period of major organogenesis, beginning just after implantation. Following sacrifice, fetal weight and evidence of malformations were recorded.

Note

Original variable names have been adapted to R conventions.

Source

http://biosun1.harvard.edu/~fitzmaur/ala

References

Price CJ, Kimmel CA, Tyl RW, Marr MC (1985) The developmental toxicity of ethylene glycol in rats and mice. Toxicological Applications in Pharmacology 81:113-127

Examples

str(ntp)
summary(ntp)

ALA documentation built on May 2, 2019, 5:39 p.m.