toenail: Multicenter study comparing two oral treatments for toe-nail...

In ALA: Data sets and examples for the book "Applied Longitudinal Analysis"

Description

The data are from a randomized, double-blind, parallel-group, multicenter study comparing two oral treatments (denoted A and B) for toe-nail infection.

Usage

data(toenail)

Format

A data frame with 1908 observations on the following 5 variables.

id

a factor with 294 levels

onycholysis

a numeric vector (0: none or mild; 1: moderate or severe)

treatment

a factor with levels A and B

month

a numeric vector

week

a numeric vector

Details

Patients were evaluated for the degree of onycholysis (the degree of separation of the nail plate from the nail-bed) at baseline (week 0) and at weeks 4, 8, 12, 24, 36, and 48 thereafter. The onycholysis outcome variable is binary (none or mild versus moderate or severe). The binary outcome was evaluated on 294 patients comprising a total of 1908 measurements.

The variable month denotes the exact timing of measurements in months. The variable week denotes scheduled visits at 0, 4, 8, 12, 24, 36, and 48 weeks.

Note

Original variable names have been adapted to R conventions. Variable visit in the source was recoded to week to make its meaning more transparent.

Source

http://biosun1.harvard.edu/~fitzmaur/ala

References

De Backer M, De Vroey C, Lesaffre E, Scheys I, De Keyser P (1998) Twelve weeks of continuous oral therapy for toenail onychomycosis caused by dermatophytes: A double-blind comparative trial of terbinafine 250 mg/day versus itraconazole 200 mg/day. Journal of the American Academy of Dermatology 38:57-63

Examples

str(toenail)
summary(toenail)

ALA documentation built on May 2, 2019, 5:39 p.m.