A series of observations of grades of psoriatic arthritis, as indicated by numbers of damaged joints.
A data frame containing 806 observations, representing visits to a psoriatic arthritis (PsA) clinic from 305 patients. The rows are grouped by patient number and ordered by examination time. Each row represents an examination and contains additional covariates.
||(numeric)||Patient identification number|
||(numeric)||Examination time in months|
||(numeric)||Clinical state of PsA. Patients in states 1, 2, 3 and 4|
|have 0, 1 to 4, 5 to 9 and 10 or more damaged joints,|
||(numeric)||Presence of five or more effusions|
||(character)||Erythrocyte sedimentation rate of less than 15 mm/h|
Gladman, D. D. and Farewell, V.T. (1999) Progression in psoriatic arthritis: role of time-varying clinical indicators. J. Rheumatol. 26(11):2409-13
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## Four-state progression-only model with high effusion and low ## sedimentation rate as covariates on the progression rates. High ## effusion is assumed to have the same effect on the 1-2, 2-3, and 3-4 ## progression rates, while low sedimentation rate has the same effect ## on the 1-2 and 2-3 intensities, but a different effect on the 3-4. data(psor) psor.q <- rbind(c(0,0.1,0,0),c(0,0,0.1,0),c(0,0,0,0.1),c(0,0,0,0)) psor.msm <- msm(state ~ months, subject=ptnum, data=psor, qmatrix = psor.q, covariates = ~ollwsdrt+hieffusn, constraint = list(hieffusn=c(1,1,1),ollwsdrt=c(1,1,2)), fixedpars=FALSE, control = list(REPORT=1,trace=2), method="BFGS") qmatrix.msm(psor.msm) sojourn.msm(psor.msm) hazard.msm(psor.msm)
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