README.md

In BioMM: BioMM: Biological-informed Multi-stage Machine learning framework for phenotype prediction using omics data

BioMM

BioMM: Biological-informed Multi-stage Machine learning framework for phenotype prediction using omics data

Features of BioMM in a nutshell

1. Applicability for various omics data modalities (e.g. methylome, transcriptomics, genomics).
2. Various biological stratification strategies.
3. Prioritizing outcome-associated functional patterns.
4. End-to-end prediction at the individual level based on biological stratified patterns.
5. Possibility for an extension to machine learning models of interest.
6. Parallel computing.

Installation

BioMM installation from Github ```{r eval=FALSE} install.packages("devtools") library("devtools") install_github("transbioZI/BioMM", build_vignettes=TRUE)

BioMM has been incorporated into the [Bioconductor](http://www.bioconductor.org/packages/devel/bioc//html/BioMM.html).
To install this package from BioConductor, start R (version "4.0") and enter:

```{r eval=FALSE}
if (!requireNamespace("BiocManager", quietly = TRUE))
    install.packages("BiocManager")
BiocManager::install("BioMM", version = "4.0")

Tutorial

The detailed instructions on how to use this package are explained in the most updated vignette.

Citation

NIPS ML4H submission: Chen, J. and Schwarz, E., 2017. BioMM: Biologically-informed Multi-stage Machine learning for identification of epigenetic fingerprints. arXiv preprint arXiv:1712.00336.

Chen, Junfang, et al. "Association of a Reproducible Epigenetic Risk Profile for Schizophrenia With Brain Methylation and Function." JAMA psychiatry (2020).

BioMM documentation built on Nov. 8, 2020, 11:04 p.m.