ELBOW: ELBOW - Evaluating foLd change By the lOgit Way

Elbow an improved fold change test that uses cluster analysis and pattern recognition to set cut off limits that are derived directly from intrareplicate variance without assuming a normal distribution for as few as 2 biological replicates. Elbow also provides the same consistency as fold testing in cross platform analysis. Elbow has lower false positive and false negative rates than standard fold testing when both are evaluated using T testing and Statistical Analysis of Microarray using 12 replicates (six replicates each for initial and final conditions). Elbow provides a null value based on initial condition replicates and gives error bounds for results to allow better evaluation of significance.

Package details

AuthorXiangli Zhang, Natalie Bjorklund, Graham Alvare, Tom Ryzdak, Richard Sparling, Brian Fristensky
Bioconductor views GeneExpression ImmunoOncology Microarray MultiChannel OneChannel RNASeq Sequencing Software Technology TwoChannel
MaintainerGraham Alvare <alvare@cc.umanitoba.ca>, Xiangli Zhang <justinzhang.xl@gmail.com>
Licensefile LICENSE
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


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ELBOW documentation built on Nov. 8, 2020, 8:14 p.m.