R/SilhouetteClustGroups.R

In MCbiclust: Massive correlating biclusters for gene expression data and associated methods

#' Slihouette validation of correlation vector clusters 
#' 
#' MCbiclust is a stochastic method and needs to be run multiple times to 
#' identify different biclusters. \code{SilhouetteClustGroups()} examines
#' the correlation vectors calculated from different runs and uses the
#' technique of examining silhouette widths to identify the number of distinct
#' clusters (and hence biclusters) found.
#' 
#' @param cor.vec.mat Correlation matrix of the correlation vectors (CVs)
#' @param max.clusters Maximum number of clusters to divide CVs into
#' @param plots True or False for whether to show silhouette plots
#' @param seed1 Value used to set random seed
#' @param rand.vec True or False for whether to add random correlation vector used for comparison
#' @return The distinct clusters of correlation vectors
#' @example example_code/example_sil.R
#' @export


SilhouetteClustGroups <- function(cor.vec.mat, max.clusters,
                                  plots = FALSE, seed1 = 100,
                                  rand.vec = TRUE){
  
    if(max.clusters >= dim(cor.vec.mat)[2]){
        max.clusters <- dim(cor.vec.mat)[2] - 1
    }
  
    if(rand.vec == TRUE){
        set.seed(seed1)
        cor.vec.mat.len <- dim(cor.vec.mat)[1]
        cor.vec.mat.add <- dim(cor.vec.mat)[2] + 1
        cor.vec.mat2 <- cbind(cor.vec.mat, rnorm(cor.vec.mat.len, 0))
    }else{
        cor.vec.mat2 <- cor.vec.mat
    }
  
    cor.dist <- as.dist(1 - abs(cor(cor.vec.mat2,use = 'pairwise.complete.obs')))
    cor.hclust <- hclust(cor.dist)
  
    silfun1 <- function(x){
        si2 <- silhouette(x = cutree(cor.hclust,k = x),dist = cor.dist)
        return(mean(si2[,3]))
    }
  
    sil.value <- vapply(seq_len(max.clusters)[-1], FUN = silfun1,FUN.VALUE = numeric(1))
  
    if(plots == TRUE) print(plot(seq_len(max.clusters-1)+1,
                                 sil.value, xlab="Number of clusters",
                                 ylab="Mean silhoette width"))
  
    k1 <- which.max(sil.value) + 1
    si2 <- silhouette(x = cutree(cor.hclust,k = k1), dist = cor.dist)
  
    if(plots == TRUE) print(plot(si2,col="red",main=""))
  
    cluster.groups <- lapply(seq_len(k1),
                             FUN=function(x) (cutree(cor.hclust,
                                                          k = k1) == x))
  
    if(rand.vec == TRUE){
        cor.vec.minus.fun <- function(x){
            return(sum(all(x==c(rep(FALSE,dim(cor.vec.mat)[2]), TRUE)),na.rm = TRUE))}
        cor.vec.minus <- unlist(lapply(cluster.groups,
                                             FUN = cor.vec.minus.fun)) == 1
        cluster.groups <- cluster.groups[!(cor.vec.minus)]
        cluster.groups <- lapply(cluster.groups,
                                 FUN = function(x) x[seq_len(dim(cor.vec.mat)[2])])
    }
    return(cluster.groups)
}