normalizePlateEffect: Normalization of plate effects

In RNAinteract: Estimate Pairwise Interactions from multidimensional features

Description

Normalization of plate effects in the screen.

Usage

normalizePlateEffect(sgi, type = "Bscore", maxit = 20, verbose = 0)

Arguments

sgi	An object of class RNAinteract
type	If type is "Bscore" (default) a Bscore-normalization is performed. If type is "spatial", a locfit regression is estimated that accounts for spatial effects.
maxit	Maximum number of iterations for locfit.
verbose	Either 0 (default, no output), 1 (minimum output), or 2 (outout).

Details

The Bscore normalization estimates row and column effects for each plate. It returns the residuals to the sum of row and column effects. The spatial normalization estimates a non-linear 2D regression for each plate and returns the residuals.

Value

An object of class RNAinteract. The returned object contains the normalization information.

Author(s)

Bernd Fischer

See Also

RNAinteract-package

Examples

data("sgi")
normalizePlateEffect(sgi)

RNAinteract documentation built on Nov. 8, 2020, 5:28 p.m.