diffVar: diffVar

In RnBeads: RnBeads

Description

This routine applies the diffVar method from the missMethyl package that determines sites exhibiting differential variability between two sample groups

Usage

diffVar(meth.matrix, inds.g1, inds.g2, adjustment.table = NULL, paired = FALSE)

Arguments

meth.matrix	Matrix containing the methylation information used to calculate differentially variable sites between the two groups
inds.g1	Indices in the phenotypic table corresponding to the first group.
inds.g2	Indices in the phenotypic table corresponding to the second group.
adjustment.table	A data.frame containing variables to adjust for in the testing
paired	Should the analysis be performed in a paired fashion. If yes, the first index in inds.g1 must correspond to the first in inds.g2 and so on.

Value

P-values as the result of the diffVar method not adjusted for multiple hypothesis testing.

Author(s)

Michael Scherer

References

Phipson, Belinda, Oshlack, Alicia (2014) DiffVar: a new method for detecting differential variability with application to methylation in cancer and aging Genome Biology 15(9):465.

RnBeads documentation built on March 3, 2021, 2 a.m.