bacon: Controlling bias and inflation in association studies using the empirical null distribution

Bacon can be used to remove inflation and bias often observed in epigenome- and transcriptome-wide association studies. To this end bacon constructs an empirical null distribution using a Gibbs Sampling algorithm by fitting a three-component normal mixture on z-scores.

Package details

AuthorMaarten van Iterson [aut, cre], Erik van Zwet [ctb]
Bioconductor views BatchEffect Bayesian GenomeWideAssociation MethylationArray MultipleComparison RNASeq Regression StatisticalMethod Transcriptomics
MaintainerMaarten van Iterson <[email protected]>
LicenseGPL (>= 2)
Package repositoryView on Bioconductor
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bacon documentation built on Nov. 1, 2018, 4 a.m.