inst/unitTests/test_findConsensusPeakRegions.R

In consensusSeekeR: Detection of consensus regions inside a group of experiences using genomic positions and genomic ranges

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# Created by Astrid Deschenes
# 2015-06-02
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## Test the findConsensusPeakRegions.R functions
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### {{{ --- Test setup ---

if(FALSE) {
    library( "RUnit" )
    library( "consensusSeekeR" )
}

### }}}

data(A549_FOSL2_01_Peaks_partial)
data(A549_FOSL2_01_NarrowPeaks_partial)
data(A549_FOXA1_01_Peaks_partial)
data(A549_FOXA1_01_NarrowPeaks_partial)

names(A549_FOXA1_01_Peaks_partial) <-
    rep("A549_FOXA1_01", length(A549_FOXA1_01_Peaks_partial))
names(A549_FOXA1_01_NarrowPeaks_partial) <-
    rep("A549_FOXA1_01", length(A549_FOXA1_01_NarrowPeaks_partial))
names(A549_FOSL2_01_Peaks_partial) <-
    rep("A549_FOSL2_01", length(A549_FOSL2_01_Peaks_partial))
names(A549_FOSL2_01_NarrowPeaks_partial) <-
    rep("A549_FOSL2_01", length(A549_FOSL2_01_NarrowPeaks_partial))

###########################################################
## Test the findConsensusPeakRegions() function parameters
###########################################################

## Test the result when a numerical is passed as narrowPeaks parameter
test.findConsensusPeakRegions_with_narrowPeaks_numerical <- function() {
    seqinfo <- Seqinfo(paste0("chr", 1:2), c(1000, 2000), NA, "mock1")
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks = 444,
            peaks = A549_FOXA1_01_Peaks_partial, chrInfo = seqinfo,
            expandToFitPeakRegion = TRUE),
            error = conditionMessage)
    exp <- "narrowPeaks must be a GRanges object"
    message <- paste0("findConsensusPeakRegions_with_narrowPeaks_numerical() ",
            "- A numerical as narrowPeaks parameter did not generated ",
            "expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when a integer is passed as peaks parameter
test.findConsensusPeakRegions_with_peaks_integer <- function() {
    seqinfo <- Seqinfo(paste0("chr", 1:2), c(1000, 2000), NA, "mock1")
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks = GRanges(),
            peaks = 444, chrInfo = seqinfo, expandToFitPeakRegion = TRUE),
            error = conditionMessage)
    exp <- "peaks must be a GRanges object"
    message <- paste0("findConsensusPeakRegions_with_peaks_integer() ",
            "- A integer as peaks parameter did not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when a list is passed as peaks parameter
test.findConsensusPeakRegions_with_peaks_list <- function() {
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks = GRanges(),
            peaks = list()), error = conditionMessage)
    exp <- "peaks must be a GRanges object"
    message <- paste0("findConsensusPeakRegions_with_narrowPeaks_integer() ",
            "- A list as peaks parameter did not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when a empty GRanges is passed as narrowPeaks parameter
## and narrowPeaks needed
test.findConsensusPeakRegions_with_narrowPeaks_empty_GRanges <- function() {
    seqinfo <- Seqinfo(paste0("chr", 1:2), c(1000, 2000), NA, "mock1")
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks = GRanges(),
            peaks = A549_FOSL2_01_Peaks_partial, chrInfo = seqinfo,
            expandToFitPeakRegion = TRUE), error = conditionMessage)
    exp <- "narrowPeaks must be a GRanges object with at least one entry"
    message <- paste0("findConsensusPeakRegions_with_narrowPeaks_empty_GRanges",
            "s() - A empty GRanges as narrowPeaks parameter did not ",
            "generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when a empty GRanges is passed as peaks parameter
test.findConsensusPeakRegions_with_peaks_empty_GRanges <- function() {
    seqinfo <- Seqinfo(paste0("chr", 1:2), c(1000, 2000), NA, "mock1")
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
            A549_FOSL2_01_NarrowPeaks_partial, peaks = GRanges(), chrInfo = seqinfo),
            error = conditionMessage)
    exp <- "peaks must be a GRanges object with at least one entry"
    message <- paste0(" findConsensusPeakRegions_with_peaks_empty_GRanges",
            "s() - A empty GRanges as peaks parameter did not generated ",
            "expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when two GRanges of different lengths are passed as
## parameters and narrowPeaks needed
test.findConsensusPeakRegions_with_diff_length_GRanges <- function() {
    seqinfo <- Seqinfo(paste0("chr", 1:2), c(1000, 2000), NA, "mock1")
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
            A549_FOSL2_01_NarrowPeaks_partial[1:3], chrInfo = seqinfo,
            peaks = A549_FOSL2_01_Peaks_partial[1:5], expandToFitPeakRegion = TRUE),
            error = conditionMessage)
    exp <- "narrowPeaks and peaks must have the same number of elements"
    message <- paste0(" findConsensusPeakRegions_with_diff_length_GRanges",
            "s() - Two GRanges of different lengths did not generated ",
            "expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when GRanges without names is passed as narrowPeaks
## parameter
test.findConsensusPeakRegions_narrowPeaks_with_no_name_GRanges <- function() {
    seqinfo <- Seqinfo(paste0("chr", 1:2), c(1000, 2000), NA, "mock1")
    gr <- GRanges(seqnames = Rle(c("chr1", "chr2"), c(1, 1)),
                ranges = IRanges(1:2, width = 2:1, names=head(letters,2)),
                strand = Rle(strand(c("-", "+")), c(1, 1)),
                score = 1:2, GC = seq(1, 0, length=2),
                seqinfo=seqinfo)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks = gr,
                    peaks = A549_FOSL2_01_Peaks_partial[2:3], chrInfo = seqinfo,
                    expandToFitPeakRegion = TRUE), error = conditionMessage)
    exp <- paste0("narrowPeaks and peaks must have defined metadata name so ",
                  "that each narrowPeaks entry can be associated to a ",
                  "peaks entry")
    message <- paste0("findConsensusPeakRegions_peaks_with_no_name_GRanges",
                      " - A GRanges without names used as narrowPeaks ",
                      "parameter did not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when GRanges without row name is passed as narrowPeaks
## parameter
test.findConsensusPeakRegions_narrowPeaks_with_no_row_name_GRanges <- function() {
    seqinfo <- Seqinfo(paste0("chr", 1:2), c(1000, 2000), NA, "mock1")
    gr <- GRanges(seqnames = Rle(c("chr1", "chr2"), c(1, 1)),
                ranges = IRanges(1:2, width = 2:1),
                strand = Rle(strand(c("-", "+")), c(1, 1)),
                score = 1:2, GC = seq(1, 0, length=2), seqinfo=seqinfo)
    gr$name = paste0("peak", 1:2)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks = gr,
            peaks = A549_FOSL2_01_Peaks_partial[2:3], chrInfo = seqinfo,
            expandToFitPeakRegion = TRUE),
            error = conditionMessage)
    exp <- paste0("narrowPeaks and peaks must have defined row names ",
                  "so that each entry can be associated to an ",
                  "experiment")
    message <- paste0(" findConsensusPeakRegions_narrowPeaks_with_",
                      "no_row_name_GRanges",
                      " - A GRanges without row name used as narrowPeaks ",
                      "parameter did not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when GRanges without names is passed as peaks
## parameter
test.findConsensusPeakRegions_peaks_with_no_name_GRanges <- function() {
    seqinfo <- Seqinfo(paste0("chr", 1:2), c(1000, 2000), NA, "mock1")
    gr <- GRanges(seqnames = Rle(c("chr1", "chr2"), c(1, 1)),
                  ranges = IRanges(1:2, width = 2:1, names=head(letters,2)),
                  strand = Rle(strand(c("-", "+")), c(1, 1)),
                  score = 10:11, GC = seq(1, 0, length=2), seqinfo=seqinfo)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
                    A549_FOSL2_01_Peaks_partial[2:3], expandToFitPeakRegion = TRUE,
                    chrInfo = seqinfo,
                    peaks = gr), error = conditionMessage)
    exp <- paste0("narrowPeaks and peaks must have defined metadata name ",
            "so that each narrowPeaks entry can be associated to ",
            "a peaks entry")
    message <- paste0(" findConsensusPeakRegions_peaks_with_no_name_GRanges",
                      " - A GRanges without names used as peaks ",
                      "parameter did not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when GRanges without row name is passed as peaks
## parameter
test.findConsensusPeakRegions_peaks_with_no_row_name_GRanges <- function() {
    seqinfo <- Seqinfo(paste0("chr", 1:2), c(1000, 2000), NA, "mock1")
    gr <- GRanges(seqnames = Rle(c("chr1", "chr2"), c(1, 1)),
                  ranges = IRanges(1:2, width = 2:1),
                  strand = Rle(strand(c("-", "+")), c(1, 1)),
                  score = 10:11, GC = seq(1, 0, length=2), seqinfo=seqinfo)
    gr$name <- paste0("peak", 1:2)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
                            A549_FOSL2_01_Peaks_partial[2:3],
                            expandToFitPeakRegion = TRUE,
                            chrInfo = seqinfo,
                            peaks = gr), error = conditionMessage)
    exp <- paste0("narrowPeaks and peaks must have defined row names ",
                  "so that each entry can be associated to ",
                  "an experiment")
    message <- paste0(" findConsensusPeakRegions_peaks_with_no_row_name_",
                      "GRanges - A GRanges without names used as peaks ",
                      "parameter did not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when two GRanges with different names are passed as
## parameters
test.findConsensusPeakRegions_with_diff_names_GRanges <- function() {
    seqinfo <- Seqinfo(paste0("chr", 1:2), c(1000, 2000), NA, "mock1")
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
            A549_FOSL2_01_NarrowPeaks_partial[3:5],
            peaks = A549_FOSL2_01_Peaks_partial[2:4], chrInfo = seqinfo,
            expandToFitPeakRegion = TRUE), error = conditionMessage)
    exp <- paste0("All narrowPeaks entry must have an equivalent peaks ",
        "entry recognizable by both an identical metadata name and an ",
        "identical row name")
    message <- paste0("findConsensusPeakRegions_with_diff_names_GRanges",
            " - Two GRanges with different names did not generated ",
            "expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when chrList is a numerical
test.findConsensusPeakRegions_with_numerical_chrList <- function() {
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
            A549_FOSL2_01_NarrowPeaks_partial[1:2],
            peaks = A549_FOSL2_01_Peaks_partial[1:2], chrInfo = 444),
            error = conditionMessage)
    exp <- paste0("chrList must be a Seqinfo object")
    message <- paste0(" findConsensusPeakRegions_with_strange_chrList",
                    " - Numerical as chrList did not generated ",
                    "expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when chrList is strange string
test.findConsensusPeakRegions_with_strange_chrList <- function() {
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
            A549_FOSL2_01_NarrowPeaks_partial[1:2],
            peaks = A549_FOSL2_01_Peaks_partial[1:2], chrInfo = "ALLO"),
            error = conditionMessage)
    exp <- "chrList must be a Seqinfo object"
    message <- paste0("findConsensusPeakRegions_with_strange_chrList",
                " - Strange string as chrList did not generated ",
                "expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when chrList is a list
test.findConsensusPeakRegions_with_list_strange_name_as_chrList <- function() {
    testList <- c("ALLO", "BYE")
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
            A549_FOSL2_01_NarrowPeaks_partial[1:2],
            peaks = A549_FOSL2_01_Peaks_partial[1:2], chrInfo = testList),
            error = conditionMessage)
    exp <- "chrList must be a Seqinfo object"
    message <- paste0("findConsensusPeakRegions_with_list_strange_name_as",
            "_chrList - List of strange string as chrList did not generated ",
            "expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when chrList with a missing length
test.findConsensusPeakRegions_with_missing_length_in_chrList <- function() {
    chrList <- Seqinfo(paste0("chr", c(1,2)), c(NA, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
                    A549_FOSL2_01_NarrowPeaks_partial[1:2],
                    peaks = A549_FOSL2_01_Peaks_partial[1:2],
                    chrInfo = chrList),
                    error = conditionMessage)
    exp <- paste0("At least one chromosome length is missing in chrList")
    message <- paste0(" findConsensusPeakRegions_with_missing_length_",
                      "in_chrList - Absent chromosome in chrList did ",
                      "not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when chrList with all non existing chromosomes
test.findConsensusPeakRegions_with_all_absent_chr_as_chrList <- function() {
    chrList <- Seqinfo(paste0("chr", c(32,101,40)),
                       c(135534747, 249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
                        A549_FOSL2_01_NarrowPeaks_partial[1:2],
                        peaks = A549_FOSL2_01_Peaks_partial[1:2],
                        chrInfo = chrList), error = conditionMessage)
    exp <- paste0("No chromosome name from chrList is present in peak")
    message <- paste0(" findConsensusPeakRegions_with_all_absent_chr_as",
                      "_chrList - All absent chromosomes in chrList did ",
                      "not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when zero as extendingSize
test.findConsensusPeakRegions_with_zero_as_extendingSize <- function() {
    chrList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
            A549_FOSL2_01_NarrowPeaks_partial[1:2],
            peaks = A549_FOSL2_01_Peaks_partial[1:2], chrInfo = chrList,
            extendingSize = 0),
            error = conditionMessage)
    exp <- "extendingSize must be a non-negative integer"
    message <- paste0("findConsensusPeakRegions_with_zero_as_extendingSize",
                    " - Xero as extendingSize did not generated ",
                    "expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when negative as extendingSize
test.findConsensusPeakRegions_with_negative_as_extendingSize <- function() {
    testList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
            A549_FOSL2_01_NarrowPeaks_partial[1:2],
            peaks = A549_FOSL2_01_Peaks_partial[1:2], chrInfo = testList,
            extendingSize = -90),
            error = conditionMessage)
    exp <- "extendingSize must be a non-negative integer"
    message <- paste0("findConsensusPeakRegions_with_negative_as_extendingSize",
                    " - Negative as extendingSize did not generated ",
                    "expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when string as extendingSize
test.findConsensusPeakRegions_with_string_as_extendingSize <- function() {
    testList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
            A549_FOSL2_01_NarrowPeaks_partial[1:2],
            peaks = A549_FOSL2_01_Peaks_partial[1:2], chrInfo = testList,
            extendingSize = "444"), error = conditionMessage)
    exp <- "extendingSize must be a non-negative integer"
    message <- paste0("findConsensusPeakRegions_with_string_as_extendingSize",
                      " - String as extendingSize did not generated ",
                      "expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when string as expandToFitPeakRegion
test.findConsensusPeakRegions_string_as_expandToFitPeakRegion <- function() {
    testList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
            A549_FOSL2_01_NarrowPeaks_partial[1:2], chrInfo = testList,
            peaks = A549_FOSL2_01_Peaks_partial[1:2],
            expandToFitPeakRegion = "444"), error = conditionMessage)
    exp <- "expandToFitPeakRegion must be a logical value"
    message <- paste0("findConsensusPeakRegions_string_as_expandToFitPeakRegion",
                " - String as expandToFitPeakRegion did ",
                "not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when numerical as expandToFitPeakRegion
test.findConsensusPeakRegions_numerical_as_expandToFitPeakRegion <- function() {
    testList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
                        c(A549_FOSL2_01_NarrowPeaks_partial,
                        A549_FOXA1_01_NarrowPeaks_partial),
                        peaks = c(A549_FOSL2_01_Peaks_partial,
                        A549_FOXA1_01_Peaks_partial), chrInfo = testList,
                        expandToFitPeakRegion=333), error = conditionMessage)
    exp <- "expandToFitPeakRegion must be a logical value"
    message <- paste0("findConsensusPeakRegions_numerical_as_",
                      "expandToFitPeakRegion - Numerical as ",
                      "expandToFitPeakRegion did not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when string as shrinkToFitPeakRegion
test.findConsensusPeakRegions_string_as_shrinkToFitPeakRegion <- function() {
    testList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
                    A549_FOSL2_01_NarrowPeaks_partial[1:2], chrInfo = testList,
                    peaks = A549_FOSL2_01_Peaks_partial[1:2],
                    shrinkToFitPeakRegion = "444"), error = conditionMessage)
    exp <- "shrinkToFitPeakRegion must be a logical value"
    message <- paste0("findConsensusPeakRegions_string_as_shrinkToFitPeakRegion",
                      " - String as shrinkToFitPeakRegion did ",
                      "not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when numerical as shrinkToFitPeakRegion
test.findConsensusPeakRegions_numerical_as_shrinkToFitPeakRegion <- function() {
    testList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
                    A549_FOSL2_01_NarrowPeaks_partial[1:2], chrInfo = testList,
                    peaks = A549_FOSL2_01_Peaks_partial[1:2],
                    shrinkToFitPeakRegion = 43), error = conditionMessage)
    exp <- "shrinkToFitPeakRegion must be a logical value"
    message <- paste0("findConsensusPeakRegions_numerical_as_shrinkToFitPeakRegion",
                      " - String as shrinkToFitPeakRegion did ",
                      "not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when string as minNbrExp
test.findConsensusPeakRegions_string_as_minNbrExp <- function() {
    testList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
                A549_FOSL2_01_NarrowPeaks_partial[1:2],
                peaks = A549_FOSL2_01_Peaks_partial[1:2],
                chrInfo = testList,
                minNbrExp = "444"), error = conditionMessage)
    exp <- "minNbrExp must be a non-negative integer"
    message <- paste0("findConsensusPeakRegions_string_as_minNbrExp",
                      " - String as minNbrExp did ",
                      "not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when zero as minNbrExp
test.findConsensusPeakRegions_zero_as_minNbrExp <- function() {
    testList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
                A549_FOSL2_01_NarrowPeaks_partial[1:2],
                peaks = A549_FOSL2_01_Peaks_partial[1:2],
                chrInfo = testList,
                minNbrExp = 0), error = conditionMessage)
    exp <- "minNbrExp must be a non-negative integer"
    message <- paste0("findConsensusPeakRegions_zero_as_minNbrExp",
                      " - Zero as minNbrExp did ",
                      "not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when negative as minNbrExp
test.findConsensusPeakRegions_negative_as_minNbrExp <- function() {
    testList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
                                A549_FOSL2_01_NarrowPeaks_partial[1:2],
                                peaks = A549_FOSL2_01_Peaks_partial[1:2],
                                chrInfo = testList,
                                minNbrExp = -1), error = conditionMessage)
    exp <- "minNbrExp must be a non-negative integer"
    message <- paste0("findConsensusPeakRegions_negative_as_minNbrExp",
                    " - Negative as minNbrExp did ",
                    "not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when numerical as minNbrExp
test.findConsensusPeakRegions_numerical_as_minNbrExp <- function() {
    testList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
                                A549_FOSL2_01_NarrowPeaks_partial[1:2],
                                peaks = A549_FOSL2_01_Peaks_partial[1:2],
                                chrInfo = testList,
                                minNbrExp = 9.3), error = conditionMessage)
    exp <- "minNbrExp must be a non-negative integer"
    message <- paste0(" findConsensusPeakRegions_numerical_as_minNbrExp",
                    " - Numerical as minNbrExp did ",
                    "not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when list of integers as minNbrExp
test.findConsensusPeakRegions_list_of_integers_as_minNbrExp <- function() {
    testList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
                            A549_FOSL2_01_NarrowPeaks_partial[1:2],
                            peaks = A549_FOSL2_01_Peaks_partial[1:2],
                            chrInfo = testList,
                            minNbrExp= c(9L, 3L)), error = conditionMessage)
    exp <- "minNbrExp must be a non-negative integer"
    message <- paste0("findConsensusPeakRegions_list_of_integers_as_minNbrExp",
                    " - List of integers as minNbrExp did ",
                    "not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when minNbrExp superior to number of experiments
test.findConsensusPeakRegions_too_big_minNbrExp <- function() {
    testList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
                                                 A549_FOSL2_01_NarrowPeaks_partial[1:2],
                                             peaks = A549_FOSL2_01_Peaks_partial[1:2],
                                             chrInfo = testList,
                                             minNbrExp = 14), error = conditionMessage)
    exp <- paste0("minNbrExp must be inferior or equal to the number of ",
                    "experiments presents in peaks. The ",
                    "number ofexperiments is known by the number of ",
                    "differents row names in peaks.")
    message <- paste0("test.findConsensusPeakRegions_too_big_minNbrExp",
                      " - Too big minNbrExp did ",
                      "not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when zero as nbrThreads
test.findConsensusPeakRegions_zero_as_nbrThreads<- function() {
    testList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
                                A549_FOSL2_01_NarrowPeaks_partial[1:2],
                                peaks = A549_FOSL2_01_Peaks_partial[1:2],
                                chrInfo = testList,
                                nbrThreads = 0), error = conditionMessage)
    exp <- "nbrThreads must be a non-negative integer"
    message <- paste0("findConsensusPeakRegions_zero_as_nbrThreads",
                    " - Zero as nbrThreads did ",
                    "not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when negative as nbrThreads
test.findConsensusPeakRegions_negative_as_nbrThreads <- function() {
    testList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
                                A549_FOSL2_01_NarrowPeaks_partial[1:2],
                                peaks = A549_FOSL2_01_Peaks_partial[1:2],
                                chrInfo = testList,
                                nbrThreads = -1), error = conditionMessage)
    exp <- "nbrThreads must be a non-negative integer"
    message <- paste0(" findConsensusPeakRegions_negative_as_nbrThreads",
                    " - Negative as nbrThreads did ",
                    "not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when numerical as nbrThreads
test.findConsensusPeakRegions_numerical_as_nbrThreads <- function() {
    testList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
                                A549_FOSL2_01_NarrowPeaks_partial[1:2],
                                peaks = A549_FOSL2_01_Peaks_partial[1:2],
                                chrInfo = testList,
                                nbrThreads = 9.3), error = conditionMessage)
    exp <- "nbrThreads must be a non-negative integer"
    message <- paste0("findConsensusPeakRegions_numerical_as_nbrThreads",
                    " - Numerical as nbrThreads did ",
                    "not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

## Test the result when list of integers as nbrThreads
test.findConsensusPeakRegions_list_of_integers_as_nbrThreads <- function() {
    testList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- tryCatch(findConsensusPeakRegions(narrowPeaks =
                            A549_FOSL2_01_NarrowPeaks_partial[1:2],
                            peaks = A549_FOSL2_01_Peaks_partial[1:2],
                            chrInfo = testList,
                            nbrThreads= c(9L, 3L)), error = conditionMessage)
    exp <- "nbrThreads must be a non-negative integer"
    message <- paste0("findConsensusPeakRegions_list_of_integers_as_nbrThreads",
                    " - List of integers as nbrThreads did ",
                    "not generated expected error.")
    checkEquals(obs, exp, msg = message)
}

###########################################################
## Test the findConsensusPeakRegions() function results
###########################################################

## Test the result when only one chromosome and one experiment
test.findConsensusPeakRegions_for_one_chromosome_one_experiment <- function() {
    seqinfo <- Seqinfo(paste0("chr", 1), NA, NA, NA)
    exp <- GRanges(seqnames = Rle(c("chr1"), c(1)),
                  ranges = IRanges(start = c(249119914, 249120334, 249123074,
                                            249132040, 249133011, 249152098,
                                            249152823, 249153205, 249157198,
                                            249167214, 249167809, 249199968,
                                            249218870),
                                   end = c(249120424, 249121174, 249123574,
                                           249132673, 249133517, 249152644,
                                           249153397, 249153705, 249157698,
                                           249167714, 249168802, 249200468,
                                           249219370)),
                  seqinfo=seqinfo)
    testList <- Seqinfo(c("chr1"), c(249250621), NA)
    obs <- findConsensusPeakRegions(narrowPeaks =
                c(A549_FOSL2_01_NarrowPeaks_partial,
                A549_FOXA1_01_NarrowPeaks_partial),
                peaks = c(A549_FOSL2_01_Peaks_partial,
                A549_FOXA1_01_Peaks_partial), chrInfo = testList,
                minNbrExp = 1, extendingSize = 250,
                expandToFitPeakRegion = TRUE, shrinkToFitPeakRegion = FALSE)
    message <- paste0(" findConsensusPeakRegions_for_one_chromosome_one",
                    "_experiment - When only one chromosome and one ",
                    "experiment did not generated expected results.")
    checkEquals(obs$consensusRanges, exp, msg = message)
}

## Test the result when ALL as chrList
test.findConsensusPeakRegions_when_ALL <- function() {
    seqinfo <- Seqinfo(paste0("chr", c(1,10)), NA, NA, NA)
    exp <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(13,8)),
                   ranges = IRanges(start = c(249119914, 249120334, 249123074,
                                              249132040, 249133011, 249152098,
                                              249152823, 249153205, 249157198,
                                              249167214, 249167809, 249199968,
                                              249218870,
                                              179374,    182194,    183469,
                                              285046,    312979,    343055,
                                              348698, 369849),
                                    end = c(249120424, 249121174, 249123574,
                                            249132673, 249133517, 249152644,
                                            249153397, 249153705, 249157698,
                                            249167714, 249168802, 249200468,
                                            249219370,
                                            179874,    182694,    183969,
                                            285546,    313479,    343555,
                                            349198, 370377)), seqinfo = seqinfo)
    chrList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- findConsensusPeakRegions(narrowPeaks =
                    c(A549_FOSL2_01_NarrowPeaks_partial,
                    A549_FOXA1_01_NarrowPeaks_partial),
                    peaks = c(A549_FOSL2_01_Peaks_partial,
                    A549_FOXA1_01_Peaks_partial), chrInfo = chrList,
                    minNbrExp = 1,
                    expandToFitPeakRegion = TRUE,
                    shrinkToFitPeakRegion = FALSE)
    message <- paste0("findConsensusPeakRegions_for_one_chromosome ",
                      " - When \"ALL\" as chrList did",
                      "not generated expected results.")
    checkEquals(obs$consensusRanges, exp, msg = message)
}

## Test the result when ALL as chrList and 2 as minNbrExp
test.findConsensusPeakRegions_when_ALL_with_minNbrExp_two <- function() {
    seqinfo <- Seqinfo(paste0("chr", c(1,10)), NA, NA, NA)
    exp <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(9, 3)),
                   ranges = IRanges(start = c(249119914, 249120334, 249123074,
                                              249132040,
                                              249152823, 249153205,
                                              249167214, 249167809, 249199968,
                                              179374,    312979,    343055),
                                    end = c(249120424, 249121174, 249123574,
                                            249132673,
                                            249153397, 249153705,
                                            249167714, 249168802, 249200468,
                                            179874,    313479,    343555)),
                                    seqinfo = seqinfo)
    chrList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- findConsensusPeakRegions(narrowPeaks =
                            c(A549_FOSL2_01_NarrowPeaks_partial,
                            A549_FOXA1_01_NarrowPeaks_partial),
                            peaks = c(A549_FOSL2_01_Peaks_partial,
                            A549_FOXA1_01_Peaks_partial),
                            expandToFitPeakRegion = TRUE,
                            shrinkToFitPeakRegion = FALSE,
                            chrInfo = chrList, minNbrExp = 2)
    message <- paste0("findConsensusPeakRegions_when_ALL_with_minNbrExp_two",
                      " - When \"ALL\" as chrList and two as minNbrExp did",
                      "not generated expected results.")
    checkEquals(obs$consensusRanges, exp, msg = message)
}

## Test the result when ALL as chrList and 2 as minNbrExp and no expending region
test.findConsensusPeakRegions_ALL_with_minNbrExp_two_no_expending <- function() {
    seqinfo <- Seqinfo(paste0("chr", c(1,10)), NA, NA, NA)
    exp <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(9,3)),
                   ranges = IRanges(start = c(249119924, 249120334, 249123074,
                                              249132040,
                                              249152864, 249153205,
                                              249167214, 249167809, 249199968,
                                              179374,    312979,    343055),
                                    end = c(249120424, 249120834, 249123574,
                                            249132540, 249153364, 249153705,
                                            249167714, 249168309, 249200468,
                                            179874,    313479,    343555)),
                   seqinfo = seqinfo)
    chrList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- findConsensusPeakRegions(narrowPeaks =
                            c(A549_FOSL2_01_NarrowPeaks_partial,
                            A549_FOXA1_01_NarrowPeaks_partial),
                            peaks = c(A549_FOSL2_01_Peaks_partial,
                            A549_FOXA1_01_Peaks_partial),
                            chrInfo = chrList,
                            minNbrExp = 2, expandToFitPeakRegion = FALSE,
                            shrinkToFitPeakRegion = FALSE)
    message <- paste0("findConsensusPeakRegions_ALL_with_minNbrExp_two_no_",
                      "expending - When two as minNbrExp ",
                      "and no expending region did ",
                      "not generated expected results.")
    checkEquals(obs$consensusRanges, exp, msg = message)
}

## Test the result when ALL as chrList and 2 as minNbrExp and no expending region
test.findConsensusPeakRegions_ALL_with_size_50_minNbrExp_two_no_expending <- function() {
    seqinfo <- Seqinfo(paste0("chr", c(1,10)), NA, NA, NA)
    exp <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(4,2)),
                   ranges = IRanges(start = c(249123274, 249167414, 249168009,
                                            249200168,    179574,    343255),
                                    end = c(249123374, 249167514, 249168109,
                                            249200268,    179674,    343355)),
                   seqinfo = seqinfo)
    chrList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- findConsensusPeakRegions(narrowPeaks =
                            c(A549_FOSL2_01_NarrowPeaks_partial,
                            A549_FOXA1_01_NarrowPeaks_partial),
                            peaks = c(A549_FOSL2_01_Peaks_partial,
                            A549_FOXA1_01_Peaks_partial),
                            chrInfo = chrList,
                            minNbrExp = 2, extendingSize = 50,
                            expandToFitPeakRegion = FALSE,
                            shrinkToFitPeakRegion = FALSE)
    message <- paste0("findConsensusPeakRegions_ALL_with_size_50_minNbrExp_",
                      "two_no_expending - When \"ALL\" as chrList, two as ",
                      "minNbrExp, size of 50 and no expending region did ",
                      "not generated expected results.")
    checkEquals(end(obs$consensusRanges)-start(obs$consensusRanges),
                rep(100L, 6), msg = message)
    checkEquals(obs$consensusRanges, exp, msg = message)
}

## Test the result when ALL as chrList and 2 as minNbrExp and no expending region
## when no datat for narrowPeaks parameters
test.findConsensusPeakRegions_ALL_with_size_50_minNbrExp_two_no_expending_no_narrowPeaks <- function() {
    seqinfo <- Seqinfo(paste0("chr", c(1,10)), NA, NA, NA)
    exp <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(4,2)),
                   ranges = IRanges(start = c(249123274, 249167414, 249168009,
                                              249200168,    179574,    343255),
                                    end = c(249123374, 249167514, 249168109,
                                            249200268,    179674,    343355)),
                   seqinfo = seqinfo)
    chrList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- findConsensusPeakRegions(peaks = c(A549_FOSL2_01_Peaks_partial,
                                              A549_FOXA1_01_Peaks_partial),
                                    chrInfo = chrList,
                                    minNbrExp = 2, extendingSize = 50,
                                    expandToFitPeakRegion = FALSE,
                                    shrinkToFitPeakRegion = FALSE)
    message <- paste0("findConsensusPeakRegions_ALL_with_size_50_minNbrExp_",
                      "two_no_expending_no_narrowPeaks - When \"ALL\" as chrList, two as ",
                      "minNbrExp, size of 50, no narrowPeaks and no expending region did ",
                      "not generated expected results.")
    checkEquals(end(obs$consensusRanges)-start(obs$consensusRanges),
                rep(100L, 6), msg = message)
    checkEquals(obs$consensusRanges, exp, msg = message)
}


## Test that left boundary inferior to zero is set to zero
test.findConsensusPeakRegions_ALL_with_one_as_left_boundary <- function() {
    seqinfo <- Seqinfo(paste0("chr", c(1,10)), NA, NA, NA)
    exp1Peak <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                   ranges = IRanges(start = c(10, 40), end = c(10, 40)),
                   name=c("peak1", "peak2"), seqinfo = seqinfo)
    names(exp1Peak)<-rep("exp1", 2)
    exp1NarrowPeak <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                        ranges = IRanges(start = c(2, 34), end = c(33, 54)),
                        name=c("peak1", "peak2"), seqinfo = seqinfo)
    names(exp1NarrowPeak)<-rep("exp1", 2)
    exp2Peak <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                    ranges = IRanges(start = c(15, 35), end = c(15, 35)),
                    name=c("peak1", "peak2"),
                    seqinfo = seqinfo)
    names(exp2Peak)<-rep("exp2", 2)
    exp2NarrowPeak <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                        ranges = IRanges(start = c(11, 32), end = c(19, 55)),
                        name=c("peak1", "peak2"),
                        seqinfo = seqinfo)
    names(exp2NarrowPeak)<-rep("exp2", 2)
    chrList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- findConsensusPeakRegions(narrowPeaks =
                                    c(exp1NarrowPeak, exp2NarrowPeak),
                                    peaks = c(exp1Peak, exp2Peak),
                                    chrInfo = chrList,
                                    minNbrExp = 2, extendingSize = 100,
                                    expandToFitPeakRegion = FALSE,
                                    shrinkToFitPeakRegion = FALSE)
    exp <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                   ranges = IRanges(start = c(1, 1),
                                    end = c(112, 137)),
                   seqinfo = seqinfo)
    message <- paste0("findConsensusPeakRegions_ALL_with_one_as_left_bondary",
                      " - When left boubdary zero or negative, the boundary ",
                      "is not modified to generate expected results.")
    checkEquals(obs$consensusRanges, exp, msg = message)
}

## Test that right boundary superior to chromosome length is set
## to chromosome length
test.findConsensusPeakRegions_ALL_with_superior_right_boundary <- function() {
    seqinfo <- Seqinfo(paste0("chr", c(1,10)), NA, NA, NA)
    exp1Peak <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                        ranges = IRanges(start = c(249250617, 135534737),
                                        end = c(249250617, 135534737)),
                        name=c("peak1", "peak2"),
                        seqinfo = seqinfo)
    names(exp1Peak)<-rep("exp1", 2)
    exp1NarrowPeak <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                              ranges = IRanges(start = c(249250614, 135534717),
                                               end = c(249250619, 135534737)),
                              name=c("peak1", "peak2"),
                              seqinfo = seqinfo)
    names(exp1NarrowPeak)<-rep("exp1", 2)
    exp2Peak <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                        ranges = IRanges(start = c(249250619, 135534740),
                                         end = c(249250619, 135534740)),
                        name=c("peak1", "peak2"),
                        seqinfo = seqinfo)
    names(exp2Peak)<-rep("exp2", 2)
    exp2NarrowPeak <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                              ranges = IRanges(start = c(249250600, 135534710),
                                               end = c(249250620, 135534746)),
                              name=c("peak1", "peak2"),
                              seqinfo = seqinfo)
    names(exp2NarrowPeak)<-rep("exp2", 2)
    chrList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- findConsensusPeakRegions(narrowPeaks =
                                        c(exp1NarrowPeak, exp2NarrowPeak),
                                    peaks = c(exp1Peak, exp2Peak),
                                    chrInfo = chrList,
                                    minNbrExp = 2, extendingSize = 100,
                                    expandToFitPeakRegion = FALSE,
                                    shrinkToFitPeakRegion = FALSE)
    exp <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                   ranges = IRanges(start = c(249250518, 135534638),
                                    end = c(249250621, 135534747)),
                   seqinfo = seqinfo)
    message <- paste0("findConsensusPeakRegions_ALL_with_one_as_left_bondary",
                      " - When right boubdary superior to chromosome length ",
                      "the boundary ",
                      "is not modified to generate expected results.")
    checkEquals(obs$consensusRanges, exp, msg = message)
}

## Test that consensus regions are shrinked to fit peak regions
test.findConsensusPeakRegions_when_shrinkToFitPeakRegion_TRUE<- function() {
    seqinfo <- Seqinfo(paste0("chr", c(1,10)), NA, NA, NA)
    exp1Peak <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                        ranges = IRanges(start = c(249250617, 135534737),
                                         end = c(249250617, 135534737)),
                        name=c("peak1", "peak2"),
                        seqinfo = seqinfo)
    names(exp1Peak)<-rep("exp1", 2)
    exp1NarrowPeak <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                              ranges = IRanges(start = c(249250614, 135534717),
                                               end = c(249250619, 135534737)),
                              name=c("peak1", "peak2"),
                              seqinfo = seqinfo)
    names(exp1NarrowPeak)<-rep("exp1", 2)
    exp2Peak <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                        ranges = IRanges(start = c(249250619, 135534740),
                                         end = c(249250619, 135534740)),
                        name=c("peak1", "peak2"),
                        seqinfo = seqinfo)
    names(exp2Peak)<-rep("exp2", 2)
    exp2NarrowPeak <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                              ranges = IRanges(start = c(249250600, 135534710),
                                               end = c(249250620, 135534746)),
                              name=c("peak1", "peak2"),
                              seqinfo = seqinfo)
    names(exp2NarrowPeak)<-rep("exp2", 2)
    chrList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- findConsensusPeakRegions(narrowPeaks =
                                        c(exp1NarrowPeak, exp2NarrowPeak),
                                    peaks = c(exp1Peak, exp2Peak),
                                    chrInfo = chrList,
                                    minNbrExp = 2, extendingSize = 200,
                                    expandToFitPeakRegion = FALSE,
                                    shrinkToFitPeakRegion = TRUE)
    exp <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                   ranges = IRanges(start = c(249250600, 135534710),
                                    end = c(249250620, 135534746)),
                   seqinfo = seqinfo)
    message <- paste0(" findConsensusPeakRegions_when_",
                      "shrinkToFitPeakRegion_TRUE",
                      " - When shrinkToFitPeakRegion set to TRUE, ",
                      "the observed results don't fit with ",
                      "the expected results.")
    checkEquals(obs$consensusRanges, exp, msg = message)
}

## Test that consensus regions empty
test.findConsensusPeakRegions_when_empty <- function() {
    seqinfo <- Seqinfo(paste0("chr", c(1,10)), NA, NA, NA)
    exp1Peak <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                        ranges = IRanges(start = c(249250617, 135534737),
                                         end = c(249250617, 135534737)),
                        name=c("peak1", "peak2"),
                        seqinfo = seqinfo)
    names(exp1Peak)<-rep("exp1", 2)
    exp1NarrowPeak <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                              ranges = IRanges(start = c(249250600, 135534733),
                                               end = c(249250618, 135534739)),
                              name=c("peak1", "peak2"),
                              seqinfo = seqinfo)
    names(exp1NarrowPeak)<-rep("exp1", 2)
    exp2Peak <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                        ranges = IRanges(start = c(249, 136),
                                         end = c(249, 136)),
                        name=c("peak1", "peak2"),
                        seqinfo = seqinfo)
    names(exp2Peak)<-rep("exp2", 2)
    exp2NarrowPeak <- GRanges(seqnames = Rle(c("chr1", "chr10"),c(1,1)),
                              ranges = IRanges(start = c(240, 130),
                                               end = c(280, 190)),
                              name=c("peak1", "peak2"),
                              seqinfo = seqinfo)
    names(exp2NarrowPeak)<-rep("exp2", 2)
    chrList <- Seqinfo(paste0("chr", c(1,10)), c(249250621, 135534747), NA)
    obs <- findConsensusPeakRegions(narrowPeaks =
                                        c(exp1NarrowPeak, exp2NarrowPeak),
                                    peaks = c(exp1Peak, exp2Peak),
                                    chrInfo = chrList,
                                    minNbrExp = 2, extendingSize = 200,
                                    expandToFitPeakRegion = FALSE,
                                    shrinkToFitPeakRegion = TRUE)
    exp <- GRanges()
    message <- paste0(" test.findConsensusPeakRegions_when_empty() ",
                      " - When shrinkToFitPeakRegion set to TRUE, ",
                      "the observed results don't fit with ",
                      "the expected results.")
    checkEquals(obs$consensusRanges, exp, msg = message)
}


## Test that consensus regions not found
test.findConsensusPeakRegions_when_not_found_region_for_a_peak <- function() {
    seqinfo <- Seqinfo(paste0("chr", c(1)), NA, NA, NA)
    exp1Peak <- GRanges(seqnames = Rle(c("chr1", "chr1"),c(1,1)),
                        ranges = IRanges(start = c(10, 109),
                                         end = c(10, 109)),
                        name=c("peak1", "peak2"),
                        seqinfo = seqinfo)
    names(exp1Peak)<-rep("exp1", 2)
    exp1NarrowPeak <- GRanges(seqnames = Rle(c("chr1", "chr1"),c(1,1)),
                              ranges = IRanges(start = c(1, 100),
                                               end = c(20, 121)),
                              name=c("peak1", "peak2"),
                              seqinfo = seqinfo)
    names(exp1NarrowPeak)<-rep("exp1", 2)
    exp2Peak <- GRanges(seqnames = Rle(c("chr1", "chr1"),c(1,1)),
                        ranges = IRanges(start = c(108, 120),
                                         end = c(108, 120)),
                        name=c("peak1", "peak2"),
                        seqinfo = seqinfo)
    names(exp2Peak)<-rep("exp2", 2)
    exp2NarrowPeak <- GRanges(seqnames = Rle(c("chr1", "chr1"),c(1,1)),
                              ranges = IRanges(start = c(100, 100),
                                               end = c(120, 140)),
                              name=c("peak1", "peak2"),
                              seqinfo = seqinfo)
    names(exp2NarrowPeak)<-rep("exp2", 2)
    chrList <- Seqinfo(paste0("chr", c(1)), c(249250621), NA)
    obs <- findConsensusPeakRegions(narrowPeaks =
                                        c(exp1NarrowPeak, exp2NarrowPeak),
                                    peaks = c(exp1Peak, exp2Peak),
                                    chrInfo = chrList,
                                    minNbrExp = 2, extendingSize = 90,
                                    expandToFitPeakRegion = FALSE,
                                    shrinkToFitPeakRegion = TRUE)
    exp <- GRanges(seqnames = Rle(c("chr1"),c(1)),
                   ranges = IRanges(start = c(19),
                                    end = c(140)),
                   seqinfo = seqinfo)
    message <- paste0(" test.findConsensusPeakRegions_when_not_found_region_for_a_peak() ",
                      " - When shrinkToFitPeakRegion set to TRUE, ",
                      "the observed results don't fit with ",
                      "the expected results.")
    checkEquals(obs$consensusRanges, exp, msg = message)
}