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netReg fits linear regression models using networkpenalization. Graph prior knowledge, in the form of biological networks, is being incorporated into the loss function of the linear model. The networks describe biological relationships such as coregulation or dependency of the same transcription factors/metabolites/etc. yielding a part sparse and part smooth solution for coefficient profiles.
Package details 


Author  Simon Dirmeier [aut, cre] 
Bioconductor views  FeatureExtraction GraphAndNetwork Network Regression Software StatisticalMethod 
Maintainer  Simon Dirmeier <[email protected]> 
License  GPL3  BSL1.0 + file LICENSE 
Version  1.4.0 
URL  https://github.com/dirmeier/netReg 
Package repository  View on Bioconductor 
Installation 
Install the latest version of this package by entering the following in R:

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