This function estimates the parameters of a zero inflated negative binomial distribution based on a real count data set based on the method of moments. The function also returns a spline fit of log mean to log size which can be used when generating new simulated data.
A matrix of counts. If you want to simulate from a ballgown
Only estimate parameters from transcripts with row means greater than threshold
p0 A vector of probabilities that the count will be zero, one for each gene/transcript.
mu The estimated negative binomial mean by method of moments for the non-zero counts
size The estimated negative binomial size by method of moments for the non-zero counts
fit A fit relating log mean to log size for use in simulating new data.
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