DPM: Merge p-values using the DPM method.

In ActivePathways: Integrative Pathway Enrichment Analysis of Multivariate Omics Data

Merge p-values using the DPM method.

Description

Merge p-values using the DPM method.

Usage

DPM(
  p_values,
  data_matrix = NULL,
  cov_matrix = NULL,
  scores_direction,
  constraints_vector
)

Arguments

p_values	A matrix of m x n p-values.
data_matrix	An m x n matrix representing m tests and n samples. NA's are not allowed.
cov_matrix	A pre-calculated covariance matrix of data_matrix. This is more efficient when making many calls with the same data_matrix. Only one of data_matrix and cov_matrix must be given. If both are supplied, data_matrix is ignored.
scores_direction	A matrix of log2 fold-change values. Datasets without directional information should be set to 0.
constraints_vector	A numerical vector of +1 or -1 values corresponding to the user-defined directional relationship between columns in scores_direction. Datasets without directional information should be set to 0.

Value

A p-value vector representing the merged significance of multiple p-values.

ActivePathways documentation built on Nov. 2, 2023, 5:12 p.m.