be2x2: Bioequivalence test of a 2x2 study

In BE: Bioequivalence Study Data Analysis

Bioequivalence test of a 2x2 study

Description

It performs conventional bioequivalence test for 2x2 study. Input is a file. Basic assumption is that the variable is distributed as a log-normal distribution. This is SAS PROC GLM style. If you want PROC MIXED style, use nlme::lme.

Usage

be2x2(Data, Columns = c("AUClast", "Cmax", "Tmax"), rtfName="")

Arguments

Data	A data.frame or a csv file name. This should have at least the following columns and variable column(s) to be tested. AUC and Cmax should be all positive values. GRP : Group or Sequence, 'RT' or 'TR' PRD : Period, 1 or 2 SUBJ : Subject ID TRT : Treatment or Drug, 'R' or 'T'
Columns	Column names of variables to be tested. This is usaully c("AUClast", "Cmax", "Tmax") or c("AUClast", "AUCinf", "Cmax", "Tmax")
rtfName	Output filename of rich text format(rtf)

Details

It performs bioequivalency tests for several variables of a 2x2 study in a data file. If you specify output filename in rtfName, the output will be saved in the file.

Value

Returns text output of equivalence test result.

Author(s)

Kyun-Seop Bae <[e-mail]>

See Also

test2x2, plot2x2

Examples

be2x2(NCAResult4BE, c("AUClast", "Cmax", "Tmax"))

BE documentation built on Jan. 7, 2023, 1:11 a.m.