sscv: Sample size using coefficient of variation (CV)

In BE: Bioequivalence Study Data Analysis

Description

It calculates sample size for the bioequivalence test on ratio using coefficient of variation (CV).

Usage

sscv(CV, DesignNo = 1, True.R = 1, Alpha = 0.1, Beta = 0.2, 
     ThetaL = 0.8, ThetaU = 1.25, nMax = 999999)

Arguments

CV	Coefficient of Variation (%)
DesignNo	Crossover design number. Design Number (treatment x sequence x period) 1 2x2x2 : RT TR (no carry-over) 2 2x4x2 (Balaam Design) : TT RR RT TR (no carry-over) 3 2x2x3 (Two-sequence Dual Design): TRR RTT (no carry-over) 4 2x3x3 : TRR RTR RRT - carry-over effect 5 2x2x4c : TRRT RTTR + carry-over effect 6 2x2x4 : TRRT RTTR - carry-over effect 7 2x4x4 : TTRR RRTT TRRT RTTR 8 3x6x3c (William Design for 3 treatments) + carry-over effect : RBA ARB BAR ABR BRA RAB 9 3x6x3 (William Design for 3 treatments) - carry-over effect : RBA ARB BAR ABR BRA RAB 10 4x4x4c (William Design for 4 treatments) + carry-over effect : RCAB ARBC BACR CBRA 11 4x4x4 (William Design for 4 treatments) - carry-over effect : RCAB ARBC BACR CBRA
True.R	True ratio of test/reference
Alpha	Alpha error level
Beta	Beta error level
ThetaL	Lower limit of equivalence criteria
ThetaU	Upper limit of equivalence criteria
nMax	Maximum subject number (sample size) per group

Details

It calculates sample size (n per group) with CV, Alpha, and Beta for bioequivalence test.

Value

Returns sample size (n per group) for bioequivalence test with ratio criteria.

Author(s)

Kyun-Seop Bae [e-mail]

Examples

sscv(25)

BE documentation built on Oct. 23, 2020, 8:33 p.m.