gamtable1: Fit a smooth GAM to Table 1 of Litchfield and Wilcoxon (1949)

In LW1949: An Automated Approach to Evaluating Dose-Effect Experiments Following Litchfield and Wilcoxon (1949)

Description

Fit a smooth GAM function to replace looking up values in Table 1 of Litchfield and Wilcoxon (1949).

Usage

gamtable1()

Details

Note that for an expected value of 37 Table 1 gives a corrected value of 9.4, but for an expected value of 63 it gives a corrected value of 90.5. To ensure that both values add to 100, I used corrected values of 9.45 and 90.55. The expected and corrected values from Table 1 are then used to build a GAM model, which is used as input to the correctval function.

Value

A gamObject that can be used to predict the corrected values (as proportions) from distexpprop5, the distance between the expected values (as proportions) and 0.5

References

Litchfield, JT Jr. and F Wilcoxon. 1949. A simplified method of evaluating dose-effect experiments. Journal of Pharmacology and Experimental Therapeutics 96(2):99-113. [link].

Examples

fit <- gamtable1()
summary(fit)
plot(fit)

LW1949 documentation built on May 2, 2019, 6:11 a.m.