Determine the effective dose for a specified percent effect from the intercept and slope of a linear regression.
A numeric vector of effects (in percents) for which to estimate the effective dose(s).
A logical scalar indicating whether to carry out a simple estimation of effective doses from the intercept and slope (TRUE), or an estimation of effective doses with confidence intervals from the Litchfield and Wilcoxon model (default, FALSE).
Follows methods outlined in Litchfield and Wilcoxon (1949). Specifically, for the 95% confidence intervals, see page 105, and equation 13 in the Appendix (corresponding to Nomograph 4).
simple=TRUE, a numeric vector the same length as
the estimated effective doses.
simple=FALSE, an n*4 numeric matrix with the given effects
pct), the effective doses (
ED), and Litchfield and
Wilcoxon's (1949) 95% confidence intervals for the effective doses
The number of rows of the matrix, n, is the length of
Litchfield, JT Jr. and F Wilcoxon. 1949. A simplified method of evaluating dose-effect experiments. Journal of Pharmacology and Experimental Therapeutics 96(2):99-113. [link].
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