Use optimization to describe the best fitting line to a dose-effect experiment following the methods of Litchfield and Wilcoxon (1949).
A data frame of dose-effect data (typically, the output from
The input data are expected to be summarized by dose. If duplicate doses are provided, an error will be thrown.
A numeric vector of length two, the estimated intercept and slope of the dose-response curve on the log10-probit scale,
Litchfield, JT Jr. and F Wilcoxon. 1949. A simplified method of evaluating dose-effect experiments. Journal of Pharmacology and Experimental Therapeutics 96(2):99-113. [link].
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