Prepare dose-effect data for evaluation.
dataprep(dose, ntot, nfx)
A numeric vector of unique, chemical concentrations (see Details).
A numeric vector of the number of individuals that were tested at each dose.
A numeric vector of the number of individuals that were affected at each dose.
The input data are expected to be summarized by dose. If duplicate doses are provided, an error will be thrown.
A data frame with eight columns (ordered by dose and proportion affected), seven numeric vectors and one logical vector:
dose = chemical concentrations.
ntot = the number of individuals that were tested at each
nfx = the number of individuals that were affected at each
rec = the record number corresponding to the input vectors
pfx = the proportion of individuals that were affected at
log10dose = log transformed dose,
bitpfx = probit transformed proportional affected,
fxcateg = effects category: 0 for none affected, 100 for all
affected, and 50 for other proportions affected.
LWkeep = logical vector identifying records to keep for
Litchfield and Wilcoxon (1949, step A1) method.
Litchfield, JT Jr. and F Wilcoxon. 1949. A simplified method of evaluating dose-effect experiments. Journal of Pharmacology and Experimental Therapeutics 96(2):99-113. [link].
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