Determine coefficients (intercept and slope) from dose-effect data using simple linear regression on the log10 dose vs. probit effect scale.
A data frame of dose-effect data (typically, the output from
A numeric vector of length two, indicating the constraints
A numeric vector of length two, the estimated intercept and slope.
Litchfield, JT Jr. and F Wilcoxon. 1949. A simplified method of evaluating dose-effect experiments. Journal of Pharmacology and Experimental Therapeutics 96(2):99-113. [link].
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