OneCompIVbolus: ADVAN-style equations
In PKPDsim: Tools for Performing Pharmacokinetic-Pharmacodynamic Simulations
OneCompIVbolus R Documentation
ADVAN-style equations
Description
Adapted from Abuhelwa et al. JPET 2015
Usage
OneCompIVbolus(d)
Arguments
d
data, a NONMEM style data frame for 1 subject with columns for TIME,
AMT, MDV, DV, CL, V
Details
Functions for calculating drug amount in each compartments of the
common pharmacokinetic models (1,2,3 compartment IV bolus, IV infusion,
and first-order absorption models)
Definitions:
- A*last: is the initial amount at the beginning of each time interval (t, t=t2-t1)
of a corresponding compartment (i.e. drug amount at the end of the last time interval)
- E* : the sum of Exit (elimination) rate constant of the corresponding compartment.
IV bolus- 1 compartment
Value
Returns a dataframe with populated columns for A1, and DV
References
Abuhelwa, A. Y., Foster, D. J. R., Upton, R. N. (2015)
ADVAN-style analytical solutions for common pharmacokinetic models. J
Pharmacol Toxicol Methods 73:42-8. DOI: 10.1016/j.vascn.2015.03.004
PKPDsim documentation built on March 7, 2023, 5:40 p.m.
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| OneCompIVbolus | R Documentation |
ADVAN-style equations
Description
Adapted from Abuhelwa et al. JPET 2015
Usage
OneCompIVbolus(d)
Arguments
d |
data, a NONMEM style data frame for 1 subject with columns for TIME, AMT, MDV, DV, CL, V |
Details
Functions for calculating drug amount in each compartments of the common pharmacokinetic models (1,2,3 compartment IV bolus, IV infusion, and first-order absorption models)
Definitions: - A*last: is the initial amount at the beginning of each time interval (t, t=t2-t1) of a corresponding compartment (i.e. drug amount at the end of the last time interval) - E* : the sum of Exit (elimination) rate constant of the corresponding compartment. IV bolus- 1 compartment
Value
Returns a dataframe with populated columns for A1, and DV
References
Abuhelwa, A. Y., Foster, D. J. R., Upton, R. N. (2015) ADVAN-style analytical solutions for common pharmacokinetic models. J Pharmacol Toxicol Methods 73:42-8. DOI: 10.1016/j.vascn.2015.03.004
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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