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Simulating and conducting four phase 12 clinical trials with correlated binary bivariate outcomes described. Uses the 'Efftox' (efficacy and toxicity tradeoff, <https://biostatistics.mdanderson.org/SoftwareDownload/SingleSoftware/Index/2>) and SPSO (Semi-Parametric Stochastic Ordering) models with Utility and Desirability based objective functions for dose finding.
Package details |
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Author | Andrew G Chapple |
Maintainer | Andrew G Chapple <achapp@lsuhsc.edu> |
License | GPL-2 |
Version | 1.5 |
Package repository | View on CRAN |
Installation |
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