RunAdaptiveEffToxTrialCORRCONTOUR: Simulates desirability based Efftox trials

In Phase12Compare: Simulates SPSO and Efftox Phase 12 Trials with Correlated Outcomes

Description

Simulates Efftox trials based on the desirability tradeoff contour.

Usage

RunAdaptiveEffToxTrialCORRCONTOUR(
  DoseStart,
  Dose,
  Hypermeans,
  Hypervars,
  Contour,
  PiLim,
  ProbLim,
  cohort,
  NET,
  NF,
  B,
  nSims,
  PMAT
)

Arguments

DoseStart	Dose level to START the EFF-Tox Trial
Dose	Vector of Doses considered in the trial
Hypermeans	6 vector of prior means
Hypervars	6 vector of prior standard deviations
Contour	4 vector used to specify the tradeoff contour.
PiLim	2 vector of acceptable limits
ProbLim	2 vector of cutoff for acceptabilities
cohort	Cohort size
NET	Maximum Sample size to run the EFFtox Trial, must be divisible by cohort
NF	Minimum sample size to begin adaptive randomization, must be divisible by count
B	Number of reps to perform in MCMC
nSims	Number of Simulated trials to run.
PMAT	Contains TRUE pi00,pi10, pi01, pi11 for each dose

Value

Trial simulation results to be processed for operating characteristics summaries.

Phase12Compare documentation built on July 31, 2020, 5:07 p.m.