RunAdaptiveEffToxTrialCORR: Simulates utility based Efftox trials

In Phase12Compare: Simulates SPSO and Efftox Phase 12 Trials with Correlated Outcomes

Description

Simulates utility based Efftox trials

Usage

RunAdaptiveEffToxTrialCORR(
  DoseStart,
  Dose,
  Hypermeans,
  Hypervars,
  UT,
  PiLim,
  ProbLim,
  cohort,
  NET,
  NF,
  B,
  nSims,
  PMAT
)

Arguments

DoseStart	Dose level to START the EFF-Tox Trial
Dose	Vector of Doses considered in the trial
Hypermeans	6 vector of prior means
Hypervars	6 vector of prior standard deviations
UT	2x2 matrix of utilities corresponding to the four binary bivariate (toxicity, efficacy) events.
PiLim	2 vector of acceptable limits
ProbLim	2 vector of cutoff for acceptabilities
cohort	Cohort size
NET	Maximum Sample size to run the EFFtox Trial, must be divisible by cohort
NF	Minimum sample size to begin adaptive randomization, must be divisible by count
B	Number of reps to perform in MCMC
nSims	Number of Simulated trials to run.
PMAT	Contains TRUE pi00,pi10, pi01, pi11 for each dose

Value

Trial simulation results to be processed for operating characteristics summaries.

Phase12Compare documentation built on July 31, 2020, 5:07 p.m.