GetPriorsSPSO: Returns prior dose-specific means and prior ESS for the SPSO...

In Phase12Compare: Simulates SPSO and Efftox Phase 12 Trials with Correlated Outcomes

Description

Uses elicited efficacy and toxicity dose-specific parameters along withlatent prior variance, dose-specific mean hypervariance, frailty variance, and global probability of monotonicity to determine dose-specific prior means for efficacy and toxicityand prints the prior effective sample size associated with the specified prior parameters.

Usage

GetPriorsSPSO(PROBST, PROBSE, tau, Var, HypVar, PGLOBAL)

Arguments

PROBST	Elicited prior toxicity probability at each dose.
PROBSE	Elicted prior efficacy probability at each dose.
tau	Frailty variance parameter.
Var	Latent parameter variance for normal probability of efficacy and toxicity.
HypVar	Hypervariance on dose specific mean efficacy and toxicity parameters.
PGLOBAL	Global monotonicity probability of dose-efficacy curve.

Value

A list contianing (1) the prior effective sample size, (2) the vector of dose-specific efficacy probability prior mean parameters and, (3) the vector of dose-specific toxicity probability prior mean parameters.

Examples

library(mvtnorm)
##Elicited probabilities of toxicity
PROBST=c(.05,.10,.15,.20,.30)
##Elicited probabilities of efficacy
PROBSE=c(.2,.4,.6,.65,.7)
##Sigma_0
Var=1
##Sigma_mu
HypVar=16
##Frailty Variance
tau=1
##Global Monotonicity Probability
PGLOBAL=.1
Z=GetPriorsSPSO(PROBST,PROBSE,tau,Var,HypVar,PGLOBAL)
Z

Phase12Compare documentation built on July 31, 2020, 5:07 p.m.