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#
# This is the user-interface definition of a Shiny web application. You can
# run the application by clicking 'Run App' above.
#
# Find out more about building applications with Shiny here:
#
# http://shiny.rstudio.com/
#
library(shiny)
library(shinythemes)
library(rhandsontable)
library(shinyWidgets)
navbarPage(
title="PopED",
collapsible = TRUE,
theme=shinytheme("cerulean"),
# Model -------------------------------------------------------------------
tabPanel("Model",tabsetPanel(
tabPanel("Model definition",
fluidRow(
column(4, offset = 4,
checkboxInput("pk_mod", label = "PK model", value = TRUE),
#h4("PK Model"),
conditionalPanel(
condition = "input.pk_mod == true",
selectInput("struct_PK_model", "Structural PK model:",
choices = list(
#"None"="NULL",
#"1-compartment" = "ff.PK.1.comp.iv",
"1-compartment, 1st-order absorption" = "ff.PK.1.comp.oral"#,
#"2-compartment" = "ff.PK.2.comp.iv",
#"2-compartment, 1st-order absorption" = "ff.PK.2.comp.oral",
#"3-compartment" = "ff.PK.3.comp.iv",
#"3-compartment, 1st-order absorption" = "ff.PK.3.comp.oral"
),
selected = "ff.PK.1.comp.oral"),
selectInput("param_PK_model", "PK model parameterization:",
choices = list(
"Clearace and Volume"="CL",
"Rate constants" = "KE"
),
selected = "CL")
)
),
#br(),
column(3,
#h4("PD Model"),
checkboxInput("pd_mod", label = "PD model", value = FALSE),
conditionalPanel(
condition = "input.pd_mod == true",
selectInput("struct_PD_model", "Structural PD Model:",
list(
#"None" = "NULL",
"Linear" = "linear",
"Emax" = "emax",
"Emax with hill coefficient" = "hill"
))
),
conditionalPanel(
condition = "input.pd_mod == true && input.pk_mod == true",
selectInput("link_fcn", label = "Link Function",
list(
"Direct Eeffect" = "direct",
"Effect compartment" = "effect",
"Turnover inhibit Kin"="inhib_kin",
"Turnover stimulate Kin"="stim_kin",
"Turnover inhibit Kout"="inhib_kout",
"Turnover stimulate Kout"="stim_kout"))
)
)
),
),
tabPanel("test",
br(),
sidebarLayout(
sidebarPanel(
sliderInput("bins",
"Number of bins:",
min = 1,
max = 50,
value = 30),
rHandsontableOutput("hot_parameter_data"),
br(),
wellPanel(
rHandsontableOutput("hot_parameter_data_2")
)
),
# Show a plot of the generated distribution
mainPanel(
#shinythemes::themeSelector(), # <--- Add this somewhere in the UI
wellPanel(plotOutput("distPlot"),
sliderInput("bins2",
"Number of bins:",
min = 1,
max = 50,
value = 30))
)
)
)
)
),
# Design -------------------------------------------------------------------
tabPanel("Design"),
# Tasks -------------------------------------------------------------------
tabPanel(
"Tasks",
tabsetPanel(
tabPanel("Plot model/design",
br(),
sidebarLayout(
sidebarPanel(
sliderInput("model_num_points",
"Number of points to plot:",
min = 50,
max = 1000,
value = 300),
checkboxInput("PI", "Show approximated PI", FALSE),
checkboxInput("DV", "Show simulated PI", FALSE),
checkboxInput("IPRED", "Show simulated PI without residual error (IPRED PI)", FALSE),
checkboxInput("separate.groups", "Separate Groups", FALSE),
actionButton("update_pmp","Update/create plot")
),
mainPanel(
plotOutput("modelPlot")
)
)
)
)
),
# Footer -------------------------------------------------------------------
footer = list(
fluidRow(
column(12, align="center",
hr(),
img(src = "poped_splash.png", height = 72, width = 72),
a(paste("PopED for R (", packageVersion("PopED"),")",sep=""),
href = "https://andrewhooker.github.io/PopED/index.html"),
div(tags$small(
img(src = "", height = 2, width = 3),
"(c) 2014-2016, Andrew C. Hooker,",
tags$br(),
img(src = "", height = 2, width = 3),
"Pharmacometrics Research Group,",
tags$br(),
img(src = "", height = 2, width = 3),
"Uppsala University,",
tags$br(),
img(src = "", height = 2, width = 3),
"Sweden")
)
)
)
)
)
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