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#
# This is the user-interface definition of a Shiny web application. You can
# run the application by clicking 'Run App' above.
#
# Find out more about building applications with Shiny here:
#
# http://shiny.rstudio.com/
#
library(shiny)
library(shinydashboard)
library(rhandsontable)
header <- dashboardHeader(
title = span(img(src = "poped_splash.png", height = 35), "PopED"),
disable = FALSE,
dropdownMenuOutput("messageMenu"),
dropdownMenu(type = "notifications",badgeStatus = "primary",
notificationItem(
text = "5 new users today",
icon("users")
),
notificationItem(
text = "12 items delivered",
icon("truck"),
status = "success"
),
notificationItem(
text = "Server load at 86%",
icon = icon("exclamation-triangle"),
status = "warning"
)
),
dropdownMenu(type = "tasks", badgeStatus = "success",
taskItem(value = 90, color = "green",
"Documentation"
),
taskItem(value = 17, color = "aqua",
"Project X"
),
taskItem(value = 75, color = "yellow",
"Server deployment"
),
taskItem(value = 80, color = "red",
"Overall project"
)
)
)
sidebar <- dashboardSidebar(
disable = FALSE,
sidebarMenu(
menuItem("Model definition", tabName = "model_def", icon = icon("bezier-curve")),
menuItem("Design definition", tabName = "design_def", icon = icon("tablets")),
menuItem("Tools", icon = icon("toolbox"), startExpanded = TRUE,
menuSubItem("Plot model and design", tabName = "plot_model_pred", icon = icon("chart-line"))
),
hr(),
menuItem("Testing", icon = icon("grimace"), tabName = "test",
badgeLabel = "new", badgeColor = "green"),
menuItem("Source code", icon = icon("file-code-o"),
href = "https://andrewhooker.github.io/PopED/",newtab = TRUE),
hr(),
menuItem("About PopED", icon = icon("info-circle"), tabName = "about", badgeColor = "green")
)
)
body <- dashboardBody(
tabItems(
# First tab content
tabItem(tabName = "model_def",
fluidRow(
box(
title = "Structural model",
status = "primary",
solidHeader = TRUE,
collapsible = TRUE,
#background = "maroon",
checkboxInput("pk_mod", label = "PK model", value = TRUE),
conditionalPanel(
condition = "input.pk_mod == true",
selectInput("struct_PK_model", "Structural PK model:",
choices = list(
#"None"="NULL",
#"1-compartment" = "ff.PK.1.comp.iv",
"1-compartment, 1st-order absorption" = "ff.PK.1.comp.oral"#,
#"2-compartment" = "ff.PK.2.comp.iv",
#"2-compartment, 1st-order absorption" = "ff.PK.2.comp.oral",
#"3-compartment" = "ff.PK.3.comp.iv",
#"3-compartment, 1st-order absorption" = "ff.PK.3.comp.oral"
),
selected = "ff.PK.1.comp.oral"),
selectInput("param_PK_model", "PK model parameterization:",
choices = list(
"Clearace and Volume"="CL",
"Rate constants" = "KE"
),
selected = "CL")
),
checkboxInput("pd_mod", label = "PD model", value = FALSE),
conditionalPanel(
condition = "input.pd_mod == true",
selectInput("DE_model", "Drug effect (DE) Model:",
list(
#"None" = "NULL",
"Linear" = "linear",
"Power" = "power",
"Emax" = "emax",
"Sigmoidal Emax" = "hill"
),
selected="hill")
),
conditionalPanel(
condition = "input.pd_mod == true && input.pk_mod == true",
selectInput("struct_PD_mod", label = "Structural PD model:",
list(
"Direct effect (base + DE)" = "direct",
"Effect compartment" = "effect",
"Turnover: inhibit Kin"="inhib_kin",
"Turnover: stimulate Kin"="stim_kin",
"Turnover: inhibit Kout"="inhib_kout",
"Turnover: stimulate Kout"="stim_kout"))
)
)
)
),
tabItem(tabName = "plot_model_pred",
fluidRow(
box(
title = "Controls",
status = "primary",
solidHeader = TRUE,
collapsible = TRUE,
#background = "maroon",
sliderInput("model_num_points",
"Number of points to plot:",
min = 50,
max = 1000,
value = 300),
checkboxInput("PI", "Show approximated PI", FALSE),
checkboxInput("DV", "Show simulated PI", FALSE),
checkboxInput("IPRED", "Show simulated PI without residual error (IPRED PI)", FALSE),
checkboxInput("separate.groups", "Separate Groups", FALSE),
actionButton("update_pmp","Update/create plot")
),
box(title="Model predictions",
status = "primary",
solidHeader = TRUE,
collapsible = TRUE,
#background = "maroon",
plotOutput("modelPlot")
)
)
),
# Second tab content
tabItem(tabName = "test",
h2("Widgets tab content"),
fluidRow(
box(
title = "Controls",
sliderInput("slider", "Number of observations:", 1, 100, 50)
),
box(
title = "Histogram",
#status = "primary",
solidHeader = TRUE,
collapsible = TRUE, background = "maroon",
plotOutput("plot1", height = 250)
),
box(title = "Controls again",
rHandsontableOutput("hot_parameter_data")
),
box(
title = "Histogram 2",
#status = "primary",
solidHeader = TRUE,
collapsible = TRUE,# background = "maroon",
plotOutput("plot2")
)
)
),
tabItem(tabName = "about",
box(
fluidRow(
column(12, align="center",
img(src = "poped_splash.png", height = 72, width = 72),
a(paste("PopED for R (", packageVersion("PopED"),")",sep=""),
href = "https://andrewhooker.github.io/PopED/index.html",
target="_blank"),
div(tags$small(
img(src = "", height = 2, width = 3),
"(c) 2014-2016, Andrew C. Hooker,",
tags$br(),
img(src = "", height = 2, width = 3),
"Pharmacometrics Research Group,",
tags$br(),
img(src = "", height = 2, width = 3),
"Uppsala University,",
tags$br(),
img(src = "", height = 2, width = 3),
"Sweden")
)
)
)
)
)
)
)
dashboardPage(header, sidebar, body)
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