crohn: Crohn's disease.

In RBesT: R Bayesian Evidence Synthesis Tools

Crohn's disease.

Description

Data set containing historical information for placebo arm of relevant studies for the treatment of Crohn's disease. The primary outcome is change from baseline in Crohn's Disease Activity Index (CDAI) over a duration of 6 weeks. Standard deviation of change from baseline endpoint is approximately 88.

Usage

crohn

Format

A data frame with 4 rows and 3 variables:

study

study

n

study size

y

mean CDAI change

References

Hueber W. et. al, Gut, 2012, 61(12):1693-1700

Examples

## Setting up dummy sampling for fast execution of example
## Please use 4 chains and 20x more warmup & iter in practice
.user_mc_options <- options(RBesT.MC.warmup=50, RBesT.MC.iter=100,
                            RBesT.MC.chains=2, RBesT.MC.thin=1)

set.seed(546346)
map_crohn <- gMAP(cbind(y, y.se) ~ 1 | study,
                  family=gaussian,
                  data=transform(crohn, y.se=88/sqrt(n)),
                  weights=n,
                  tau.dist="HalfNormal", tau.prior=44,
                  beta.prior=cbind(0,88))
## Recover user set sampling defaults
options(.user_mc_options)

RBesT documentation built on Aug. 22, 2023, 1:08 a.m.