# postmix: Conjugate Posterior Analysis In RBesT: R Bayesian Evidence Synthesis Tools

## Description

Calculates the posterior distribution for data data given a prior priormix, where the prior is a mixture of conjugate distributions. The posterior is then also a mixture of conjugate distributions.

## Usage

  1 2 3 4 5 6 7 8 9 10 postmix(priormix, data, ...) ## S3 method for class 'betaMix' postmix(priormix, data, n, r, ...) ## S3 method for class 'normMix' postmix(priormix, data, n, m, se, ...) ## S3 method for class 'gammaMix' postmix(priormix, data, n, m, ...) 

## Arguments

 priormix prior (mixture of conjugate distributions). data individual data. If the individual data is not given, then summary data has to be provided (see below). ... includes arguments which depend on the specific case, see description below. n sample size. r Number of successes. m Sample mean. se Sample standard error.

## Details

A conjugate prior-likelihood pair has the convenient property that the posterior is in the same distributional class as the prior. This property also applies to mixtures of conjugate priors. Let

p(θ;w,a,b)

denote a conjugate mixture prior density for data

y|θ ~ f(y|θ),

where f(y|θ) is the likelihood. Then the posterior is again a mixture with each component k equal to the respective posterior of the kth prior component and updated weights w'_k,

p(θ;w',a',b'|y) = ∑_{k=1}^K w'_k * p(θ;a'_k,b'_k|y).

The weight w'_k for kth component is determined by the marginal likelihood of the new data y under the kth prior distribution which is given by the predictive distribution of the kth component,

w'_k \propto w_k \int p_k(u;a_k,b_k) f(y|u) du = w^*_k .

The final weight w'_k is then given by appropriate normalization, w'_k = w^*_k / ∑_{k=1}^K w^*_k. In other words, the weight of component k is proportional to the likelihood that data y is generated from the respective component, i.e. the marginal probability; for details, see for example Schmidli et al., 2015.

Note: The prior weights w_k are fixed, but the posterior weights w'_k \neq w_k still change due to the changing normalization.

The data y can either be given as individual data or as summary data (sufficient statistics). See below for details for the implemented conjugate mixture prior densities.

## Methods (by class)

• betaMix: Calculates the posterior beta mixture distribution. The individual data vector is expected to be a vector of 0 and 1, i.e. a series of Bernoulli experiments. Alternatively, the sufficient statistics n and r can be given, i.e. number of trials and successes, respectively.

• normMix: Calculates the posterior normal mixture distribution with the sampling likelihood being a normal with fixed standard deviation. Either an individual data vector data can be given or the sufficient statistics which are the standard error se and sample mean m. If the sample size n is used instead of the sample standard error, then the reference scale of the prior is used to calculate the standard error. Should standard error se and sample size n be given, then the reference scale of the prior is updated; however it is recommended to use the command sigma to set the reference standard deviation.

• gammaMix: Calculates the posterior gamma mixture distribution for Poisson and exponential likelihoods. Only the Poisson case is supported in this version.

## Supported Conjugate Prior-Likelihood Pairs

 Prior/Posterior Likelihood Predictive Summaries Beta Binomial Beta-Binomial n, r Normal Normal (fixed σ) Normal n, m, se Gamma Poisson Gamma-Poisson n, m Gamma Exponential Gamma-Exp (not supported) n, m

## References

Schmidli H, Gsteiger S, Roychoudhury S, O'Hagan A, Spiegelhalter D, Neuenschwander B. Robust meta-analytic-predictive priors in clinical trials with historical control information. Biometrics 2014;70(4):1023-1032.

## Examples

  1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 # binary example with individual data (1=event,0=no event), uniform prior prior.unif <- mixbeta(c(1, 1, 1)) data.indiv <- c(1,0,1,1,0,1) posterior.indiv <- postmix(prior.unif, data.indiv) print(posterior.indiv) # or with summary data (number of events and number of patients) r <- sum(data.indiv); n <- length(data.indiv) posterior.sum <- postmix(prior.unif, n=n, r=r) print(posterior.sum) # binary example with robust informative prior and conflicting data prior.rob <- mixbeta(c(0.5,4,10),c(0.5,1,1)) posterior.rob <- postmix(prior.rob, n=20, r=18) print(posterior.rob) # normal example with individual data sigma <- 88 prior.mean <- -49 prior.se <- sigma/sqrt(20) prior <- mixnorm(c(1,prior.mean,prior.se),sigma=sigma) data.indiv <- c(-46,-227,41,-65,-103,-22,7,-169,-69,90) posterior.indiv <- postmix(prior, data.indiv) # or with summary data (mean and number of patients) mn <- mean(data.indiv); n <- length(data.indiv) posterior.sum <- postmix(prior, m=mn, n=n) print(posterior.sum) 

RBesT documentation built on Nov. 24, 2021, 5:07 p.m.